Abstract: AIM: To evaluate the efficacy of amlodipine plus telmisartan in improving microalbuminuria of subjects with hypertension and diabetes.METHODS: Electronic databases of OVID-LWW, CNKI and Wanfang were searched to collect randomized controlled trials(RCT) by interventions of amlodipine plus telmisartan in improving microalbuminuria of subjects with hypertension and diabetes, the methodological quality of the trials and extracted valid data for Meta-analysis was evaluated.RESULTS: 5 RCT and 500 patients were included. Test group were treated by amlodipine plus telmisartan, the control group were treated by telmisartan. Meta analysis showed that no statistically significant was found for 24 h microalbuminuria between two groups before treatment, but statistically significant was found after treatment. CONCLUSION: Amlodipine plus telmisartan can improve 24 h microalbuminuria of subjects with hypertension and diabetes, hypertension and diabetes 24 h trace urine protein content to good effect. However, because of the lower methodological quality literature, it is still necessary to need a large sample, and long-term adverse reactions follow-up.

Key words: Amlodipine, Telmisartan, Hypertension, Diabetes, Meta analysis