Abstract: AIM: To explore the effects and the mechanism of resveratrol on platelet aggregation in hyperlipidemia rats.METHODS: Experimental hyperlipidemia rats were ig administrated of resveratrol (50 mg·kg^-1·d^-1) or vehicle for 30 d. The levels of TC, TG, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), NO, endothelial nitric oxide synthase (eNOS), granulemembrane protein-140(GMP-140),thromboxaneB₂ (TXB₂),6-keto -prostaglandin F_1α (6-keto-PGF_1α) and platelet maximal aggregation rate(MAR)which was induced by ADP in 5 minute were measured.RESULTS: Compared with the high fat diet (HFD) group, the levels of TG, TC,LDL-C were decreased respectively by 19%, 31%,51% and the level of HDL-C increased in 1.33 folds after the rats fed and ig resveratrol (50 mg·kg^-1·d^-1) for 30 d. The activities of SOD and eNOS and the content of NO and 6-keto-PGF_1α in resveratrol group were increased (P<0.01).And the contents of MDA, GMP-140,TXB₂ and MAR in resveratrol group were decreased (P<0.05).CONCLUSION: Platelet aggregation rate was decreased in experimental hyperlipidemia rats by i.g. administration of resveratrol, its mechanism closely correlates with decline of plasma lipid and with anti- peroxide of lipid , protecting vaso endothelial cells , improving the synthesis of NO , keeping the balance of TXA₂ and PGI₂ in tissue or plasma and the balance between extracellular calcium and intracellular calcium.

Key words: Resveratrol, Hyperlipidemia, Platelet aggregation