Effects of aerosol inhalation of hypertonic saline on severe pneumonia in children

Abstract

Abstract: AIM: To observe the efficacy of aerosol inhalation of hypertonic saline on severe pneumonia in children.METHODS: Patients with severe pneumonia in the pediatric intensive care unit were randomly divided into experiment group and control group. With the same comprehensive treatment, the patients in the experiment group were treated with aerosol inhalation of hypertonic saline (4.3% NaCl) and budesonide 0.5 mg; while the patients in the control group were treated with aerosol inhalation of physiological saline (0.9% NaCl) and budesonide 0.5 mg. The time of symptoms and signs disappeared days and costs for hospitalization were observed.RESULTS: Compared with control group, the duration of continuous positive airway pressure (CPAP), cough and breath retraction were reduced, and the costs of hospitalization were also decreased(P<0.05).CONCLUSION: The better efficacy is achieved by treated with hypertonic saline in children with severe pneumonia. This strategy is worthy of clinical application.

Key words: Children, Severe pneumonia, Hypertonic saline, Budesonide, Inhalation

CLC Number:

R722.13

LIU Ying, SHI Dao-hua, WANG Shi-biao, GUO Xiao-feng, ZHU Jie-jun. Effects of aerosol inhalation of hypertonic saline on severe pneumonia in children[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(7): 804-806.

References

[1] Kuzik BA,Flavin MP,Kent S, et al. Effect of inhaled hypertonic saline on hospital admission rate in children with viral bronchiolitis: a randomized trial[J]. CJEM,2010, 12(6):477-484.
[2] Kadir MA,Mollah AH,Basak R, et al. Comparative efficacy of combined nebulized salbutamol with ipratropium bromide and nebulized adrenaline to treat children with acute bronchiolitis[J]. Mymensingh Med J,2009, 18(2):208-214.
[3] 文政,廖莉,胡呈凤,等. 3%高渗盐水联合氨溴索高频雾化吸入治疗毛细支气管炎43例临床观察[J]. 儿科药学杂志,2012, 18(7):19-21.
[4] 中华医学会儿科学分会呼吸学组. 儿童社区获得性肺炎管理指南(试行)(上)[J]. 中华儿科杂志,2007, 45(2):83-90.
[5] 中华医学会儿科学分会呼吸学组. 儿童社区获得性肺炎管理指南(试行)(下)[J]. 中华儿科杂志,2007, 45(3):223-230.
[6] Mathew JL. Hypertonic saline nebulization for bronchiolitis[J]. Indian Pediatr,2008, 45(12):987-989.
[7] 刘亚秋,夏汉兵,丘喜琴. 鼻塞式CPAP治疗小儿重症妇幼疗效观察[J]. 中国妇幼保健,2008, 23(24):3048-3049.
[8] Tal G,Cesar K,Oron A, et al. Hypertonic saline/epinephrine treatment in hospitalized infants with viral bronchiolitis reduces hospitalization stay: 2 years experience[J]. Isr Med Assoc J,2006, 8(3):169-173.
[9] Chaudhry K,Sinert R. Evidence-based emergency medicine/systematic review abstract. Is nebulized hypertonic saline solution an effective treatment for bronchiolitis in infants[J]？ Ann Emerg Med,2010, 55(1):120-122.
[10] Ipek IO,Yalcin EU,Sezer RG, et al. The efficacy of nebulized salbutamol, hypertonic saline and salbutamol/hypertonic saline combination in moderate bronchiolitis[J]. Pulm Pharmacol Ther,2011, 24(6):633-637.
[11] Lahti E,Peltola V,Waris M, et al. Induced sputum in the diagnosis of childhood community-acquired pneumonia[J]. Thorax,2009, 64(3):252-257.

[1]	CHEN Jian, LAN Yu, WU Yong, SHEN Boxiong. Effects of intestinal flora disturbance on postoperative cognitive dysfunction in patients with inhalation anesthesia [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 639-644.
[2]	LI Jiajia, CHEN Mengmeng, WANG Ruixian, HUANG Mengmeng, LI Jun, SHANGGUAN Wangning. Effects of alfentanil on tracheal intubation during tonsillectomy in children: A randomized double-blind study [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(2): 184-189.
[3]	WANG Yuanyuan, HONG Yu, ZHANG Lei, YIN Fangxiong, LEI Ting, ZHU Xi. Establishment and application of DUE criteria for human albumin in pediatric patients [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(6): 653-661.
[4]	XUAN Miaoyan, XU Zhen. Correlation between changes of intestinal flora in children with Kawasaki disease and the levels of specific transcription factors RORγt, FOXP3 and T lymphocyte subsets [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(2): 154-160.
[5]	LI Jing, Ma Lijuan, YUAN Yuan, WANG Jie, YU Changzhi, ZHAO Jun. Relationship between gene polymorphism of inhaled glucocorticosteroids budesonide and efficacy in asthma [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(11): 1250-1258.
[6]	PAN Luping, SHI Wujie, SHEN Zhipeng. Efficacy and safety of etoposide combined with carboplatin in children with recurrent medulloblastoma [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(2): 189-195.
[7]	JIANG Li, LI Yuning, PANG Lihong, ZHANG Xingdao, WANG Fang. N-acetylcysteine combined with pulmonary surfactant alleviates neonatal severe fetus seizure syndrome through regulating fetal inflammatory factors and oxygenation [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(1): 81-86.
[8]	YING Haifeng, ZHANG Weiping, YOU Kuangzhang, CHEN Lingyang. Analgesia effect of small amount of buprenorphine on children undergoing laparoscopic hernia repair under general anesthesia [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(8): 916-921.
[9]	WANG Shibiao, WANG Chengyi, WENG Bin, GUO Xiaofeng, LIN Hai. Comparison of the efficacy of non-invasive USCOM and milrinone in children with severe pneumonia and heart failure and its effect on brain natriuretic peptide levels [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(12): 1402-1407.
[10]	HE Jianguo, YUAN Liyong, CHEN Lin, JIANG Juan. Preemptive analgesia effect of parecoxib sodium on children undergoing laparoscopic appendectomy [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(6): 705-708.
[11]	ZHU Xiaojie, KONG Ying, LIU Qi, LU Yang, ZHAO Di, LI Ning, CHEN Xijing . Preparation and evaluation of inhaled dry powders based on folic acid-conjugated Docetaxel nanoparticles [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(5): 495-500.
[12]	ZHANG Peihong, CHEN Xiaohong, CHEN Bingrong, LI Huajun. Study on asthmatic children serum cytokine levels and saccharomyces boulardii intervention [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(3): 332-336.
[13]	ZHAO Zhiqiang, XI Zan, YAN Pengfei . Clinical value of combined detection of amylase, lipase and procalcitonin in the diagnosis of children with acute pancreatitis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(11): 1265-1268.
[14]	MAN Zhen-zhen, SUN Shu-fang, HAO Wan-ming, HAN Wei, TANG Hua-ping. Nebulized Budesonide suspension in maintenance therapy of patients with severe persistent asthma [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(5): 548-551.
[15]	TANG Zhi-hua, WANG Wei, DING Jie-wei. Distribution of aminophylline after aerosol inhalation in beagles [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(2): 150-155.