Research progress on mechanism of let-7 expression regulation

Abstract

Abstract: MicroRNA let-7 regulates stem cell differentiation and normal development, as well act as tumor suppressor. Current studies found it is regulated by Lin28, histone demethylase, miR-107 and NF90-NF45 complex at transcriptional and post-transcriptional level. Furthermore, there are lin28 dependent and -independent regulatory circuits to modulate the expression level of let-7. Here is to make a review on regulation of let-7 expression.

Key words: MicroRNA, Let-7, Lin28, Expression regulation

CLC Number:

R968

ZHAN Min, CHEN Yao, ZHOU Hong-hao. Research progress on mechanism of let-7 expression regulation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(7): 813-817.

References

[1] Boyerinas B, Park SM, Hau A, et al. The role of let-7 in cell differentiation and cancer [J]. Endocr Relat Cancer, 2010, 17(1): F19-F36.
[2] Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [J]. Nature, 2000, 403(6772): 901-906.
[3] Ruby JG, Jan C, Player C, et al. Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans [J]. Cell, 2006, 127(6): 1193-1207.
[4] Gregory RI, Chendrimada TP, Cooch N, et al. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing [J]. Cell, 2005, 123(4): 631-640.
[5] Newman MA, Thomson JM, Hammond SM. Lin28 interaction with the Let-7 precursor loop mediates regulated microRNA processing [J]. Rna, 2008, 14(8): 1539-1549.
[6] Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28 [J]. Science, 2008, 320(5872): 97-100.
[7] Piskounova E, Viswanathan SR, Janas M, et al. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28 [J]. J Biol Chem, 2008, 283(31): 21310-21314.
[8] Heo I, Joo C, Cho J, et al. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA [J]. Mol Cell, 2008, 32(2): 276-284.
[9] Hagan JP, Piskounova E, Gregory RI. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells [J]. Nat Struct Mol Biol, 2009, 16(10): 1021-1025.
[10] Heo I, Joo C, Kim YK, et al. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation [J]. Cell, 2009, 138(4): 696-708.
[11] Piskounova E, Polytarchou C, Thornton JE, et al. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms [J]. Cell, 2011, 147(5): 1066-1079.
[12] Mitra D, Das PM, Huynh FC, et al. Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e [J]. J Biol Chem, 2011, 286(47): 40531-40535.
[13] He J, Nguyen AT, Zhang Y. KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia [J]. Blood, 2011, 117(14): 3869-3880.
[14] Chen PS, Su JL, Cha ST, et al. miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans [J]. J Clin Invest, 2011, 121(9): 3442-3455.
[15] Sakamoto S, Aoki K, Higuchi T, et al. The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway [J]. Mol Cell Biol, 2009, 29(13): 3754-3769.
[16] Iliopoulos D, Hirsch HA, Struhl K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation [J]. Cell, 2009, 139(4): 693-706.
[17] Wang DJ, Legesse-Miller A, Johnson EL, et al. Regulation of the let-7a-3 promoter by NF-kappaB [J]. PLoS One, 2012, 7(2): e31240.
[18] Dangi-Garimella S, Yun J, Eves EM, et al. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving Lin28 and let-7 [J]. Embo J, 2009, 28(4): 347-358.
[19] Chang TC, Zeitels LR, Hwang HW, et al. Lin28B transactivation is necessary for Myc-mediated let-7 repression and proliferation [J]. Proc Natl Acad Sci U S A, 2009, 106(9): 3384-3389.
[20] Sampson VB, Rong NH, Han J, et al. MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells [J]. Cancer Res, 2007, 67(20): 9762-9770.
[21] Rybak A, Fuchs H, Smirnova L, et al. A feedback loop comprising Lin28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment [J]. Nat Cell Biol, 2008, 10(8): 987-993.
[22] Zisoulis DG, Kai ZS, Chang RK, et al. Autoregulation of microRNA biogenesis by let-7 and Argonaute [J]. Nature, 2012, 486(7404): 541-544.
[23] Rybak A, Fuchs H, Hadian K, et al. The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2 [J]. Nat Cell Biol, 2009, 11(12): 1411-1420.
[24] Diederichs S, Haber DA. Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression [J]. Cell, 2007, 131(6): 1097-1108.
[25] Forman JJ, Legesse-Miller A, Coller HA. A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence [J]. Proc Natl Acad Sci U S A, 2008, 105(39): 14879-14884.
[26] Jakymiw A, Patel RS, Deming N, et al. Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells [J]. Genes Chromosomes Cancer, 2010, 49(6): 549-559.
[27] Wang S, Tang Y, Cui H, et al. Let-7/miR-98 regulate Fas and Fas-mediated apoptosis [J]. Genes Immun, 2011, 12(2): 149-154.
[28] Geng L, Zhu B, Dai BH, et al. A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis [J]. Biochem Biophys Res Commun, 2011, 408(3): 494-499.
[29] Hammell CM, Karp X, Ambros V. A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans [J]. Proc Natl Acad Sci U S A, 2009, 106(44): 18668-18673.
[30] Chandrasekar V, Dreyer JL. MicroRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity [J]. Mol Cell Neurosci, 2009, 42(4): 350-362.
[31] He Y, Yang C, Kirkmire CM, et al. Regulation of opioid tolerance by let-7 family microRNA targeting the mu opioid receptor [J]. J Neurosci, 2010, 30(30): 10251-10258.
[32] Lopez-Bellido R, Barreto-Valer K, Sanchez-Simon FM, et al. Cocaine Modulates the Expression of Opioid Receptors and miR-let-7d in Zebrafish Embryos [J]. PLoS One, 2012, 7(11): e50885.