Progress on influence of cytochrome P450 oxidoreductase polymorphisms on cytochrome P450 monoxyfenases

Abstract

Abstract: Cytochrome P450 oxidoreductase (POR) is the only electron dornor for transferring electrons from NADPH to all microsome Cytochrome P450 monooxygenases(CYP).CYP is involved in the metabolism and transformation of drugs ,steroids and other substances. Polymorphisms and genetic variations of POR change the activity of CYP, resulting in P450 oxidoreductase deficiency (PORD), differences on drug metabolism and reaction. The review summarizes the recent research progress on influence of POR genetic polymorphisms on CYP from three parts: structure and function, disease and influence on enzymes.

Key words: Cytochrome P450 oxidoreductase, Cytochrome P450 monooxygenases, P450 oxidoreductase deficiency, Genetic polymorphism, Genetic variation

CLC Number:

R968

HUANG Lu, YANG Guo-ping. Progress on influence of cytochrome P450 oxidoreductase polymorphisms on cytochrome P450 monoxyfenases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(7): 818-823.

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