Abstract: AIM: To observe the change of female estrogens on effects and side effects of sufentanil for postoperative intravenous analgesia after transabdominal hysteromyomectomy(TAH).METHODS: Sixty patients for TAH,ASA I-II ,were divided into two groups:I (premenopansal group)and Ⅱ(postmenopausal group), with 30 cases each. Sufentanil 100 mg and ondanstrone 8 mg were diluted with saline into 100 mL and continuously infused at the rate of 2 mL/h before 30 min end of operation.Visual analogue scale(VAS),Ramsay sedation scale and side effects were recorded at 4,8, 12,24,36,and 48 h postoperatively.RESULTS: Two groups had no significant difference in analgesic effects and sedation scale,VAS of all groups were below 3, sedation scale of two groups were lower than 4.The incidence of side effects -respiratory depression,nausea,vomiting and pruritus were no significant difference in the two groups.CONCLUSION: The change of female estrogens has no significant effects on sufentanil postoperative intravenous analgesia after TAH. Intravenous sufentanil can produce reliable postoperative analgesia for patients with TAH and with fewer adverse effects.

Key words: Sufentanil, Analgesia, Menopause, TAH