Abstract: AIM: To investigate the effects of advanced using flurbiprofen and dexmedetomidine in children undergoing tonsillectomy.METHODS: 60 children undergoing tonsillectomy were randomly divided into 3 groups, the control group (groupⅠ,n=20), flurbiprofen group(groupⅡ,n=20), flurbiprofen and dexmedetomidine group (groupⅢ,n=20). Children were received 2 mL saline, 1 mg/kg fiurbiprofen, 1 mg/kg fiurbiprofen and 0.5 μg/kg dexmedetomidine before induction in each group respectively. After intravenvous induction, all children were maintained with sevoflurane. Blood pressure and heart rate were recorded during operation. Agitation Scale (pediatric anesthesia emergence delirium,PAED) and analgesia (children and infants postoperative pain scale,CHIPPS) was assessed at extubation and after 5,10,15,30 minutes.RESULTS: Compared with groupⅠ,there were significant reduction in perioperative and postanesthetic recovery dosage of fentanyl in group Ⅲ.The occurrence of hypoxemia in PACU were 25%,20% and 5% in groupⅠ, Ⅱ and Ⅲ respectively. The occurrence of hypoxemia in group Ⅲ was significantly lower(P<0.01) and the same as incidence of postoperative nausea and vomiting (30%)(P<0.01). In comparison with groupⅠ, there were slower heart rate in postextubation 5 and 10 minutes,decreased PAED score and CHIPPS scale in time of extubation, postextubation 5 minutes,10 minutes in group Ⅲ. No difference was observed about time of eye open and extubation among three groups.CONCLUSION: Advanced use flurbiprofen and dexmedetomidine can relieve pain,provide stable hemodynamics and reduce incidence of postoperative nausea,vomiting and agitation.

Key words: Flurbiprofen , Dexmedtomidine, Tonsillectomy , Children