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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2014, Vol. 19 ›› Issue (11): 1312-1316.

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A new regulatory target of the metabolic syndrome :the farnesoid X receptor

ZHU Hong1, XU Zhu-mei2, XIAO Jian2   

  1. 1 Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University;
    2 School of Pharmacy, Wenzhou Medical Universyty, Wenzhou 325000,Zhejiang,China
  • Received:2013-12-27 Revised:2014-10-28 Online:2014-11-26 Published:2014-12-09

Abstract: The farnesoid X receptor(FXR) is a nuclear receptor of bile acids, which plays an important role in bile acid regulation, lipid and glucose homeostasis. It associates with metabolic syndrome closely. Thus, FXR is probably a new regulatory target in the treatment of metabolic syndrome.This paper discusses the research progress about the FXR and bile acid regulation, lipid and glucose homeostasis.

Key words: FXR, bile acid, lipid metabolism, glucose metabolism

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