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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2014, Vol. 19 ›› Issue (3): 351-355.

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Adervances in the research of multidrug resistance-associated protein 1 and its relationship with tumor

LI Jun1, JIANG Kui2, ZHANG Xue-mei1   

  1. 1Medical College of Dalian University, Dalian 116622,Liaoning,China;
    2Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning ,China
  • Received:2013-08-01 Revised:2014-02-24 Online:2014-03-26 Published:2014-04-10

Abstract: Multidrug resistance (MDR) is a major impediment to the cancer chemotherapy. Multidrug resistance associated protein 1(MRP1/ABCC1) is thought to be one of the main transmembrane proteins that mediate tumor multidrug resistance. Exploring its structure and function,as well as the relationship between MRP1/ABCC1 and tumor, will be beneficial to provide an optimal strategy and evaluate the prognosis of tumor.

Key words: multidrug resistance associated protein 1, multidrug resistance, tumor

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