Role of heparanase in the invasion and metastasis of tumor and its mechanism

Abstract

Abstract: Heparanase(HPSE) is heparan sulfate-degrading enzymes, which could specifically degrade the heparan sulfate proteoglycans associated with the cell surface, extracellular matrix and basement membrane. It can promote tumor invasion, metastasis and angiogenesis, moreover participate in the process of pathophysiological as immunological surveillance and embryo impantation. This review will summerize the role of HPSE in facilitating tumor metastatic and the advance in its inhibitor.

Key words: heparanase, tumor metastasis, angiogenesis

CLC Number:

NIE Chen-lin, CHEN Xiao-peng. Role of heparanase in the invasion and metastasis of tumor and its mechanism[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(7): 812-817.

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