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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2014, Vol. 19 ›› Issue (9): 991-994.

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Protection and mechanism of extract of Phyllanthus emblica L. on focal cerebral ischemia-reperfusion injury in rats

CHEN Chuang   

  1. Emergency Department, Branch of Zhejiang Hospital, Hangzhou 310030, Zhejiang, China
  • Received:2014-05-27 Revised:2014-09-01 Online:2014-09-26 Published:2014-09-26

Abstract: AIM: To study the protection and mechanisms of extract of Phyllanthus emblica L.(EPE) on focal cerebral ischemia-reperfusion injury in rats. METHODS: The cerebral ischemia-reperfusion rats' models were created by the middle cerebral artery occlusion by modified suture method. The neurological function scores were observed, the infarct size was measured by TTC staining, and the contents of SOD, MDA, NO, IL-1β, IL-6, iNOS and NF-κB in brain tissue were measured. RESULTS: Compared with the model group, EPE could significantly reduce the neurological function scores, decrease the cerebral infarct size, increase the activity of SOD, and reduce the contents of MDA, NO, IL-1β, IL-6, iNOS and NF-κB in brain tissue. CONCLUSION: EPE has significant protection on cerebral ischemia-reperfusion injury in rats due to increases the antioxidant activity and inhibit inflammatory reaction.

Key words: Phyllanthus emblica L., extract, cerebral ischemia-reperfusion, antioxidant, free radical, inflammatory

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