Exploration on analgesia effect of anthocyanins from Ligustrum vicaryi fruit

Abstract

Abstract: AIM: To investigate the analgesic effect mechanism of anthocyanins from Ligustrum vicaryi. METHODS: Experimental animals were divided into 5 groups (n=8): normal saline control group (NS);aspirin control group (Asp);high-concentration anthocyanins group (HA);medium-concentration anthocyanins group (MA);low-concentration anthocyanins group (LA). We observed the analgesia effect of different concentration anthocyanins by hot-plate test and acetic acid writhing test. The activity of superoxide dismutase (SOD) and the contents of nitric oxide (NO) and prostaglandin E₂(PGE₂) in blood serum were determined to analysis the analgesia mechanism. RESULTS: The pain threshold of mice was enhanced and the times of twist body was decreased by medium-concentration and high-concentration anthocyanins. The activity of SOD was increased and the contents of NO and PGE₂ were reduced in blood serum. CONCLUSION: Anthocyanins of Ligustrum vicaryi has definite analgesic effect, which was related to increasing the activity of SOD and decreasing the contents of NO and PGE₂.

Key words: anthocyanins, analgesic, SOD, NO, PGE₂

CLC Number:

R965.2

WANG Jing, WANG Hai-hua, JIANG Yu-xin, ZHOU Ping-ping, WANG Jian-an. Exploration on analgesia effect of anthocyanins from Ligustrum vicaryi fruit[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(1): 38-42.

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