Research progress of therapy of intravenous immunoglobulin on neuropathic pain

Abstract

Abstract: Intravenous use of immunoglobulin exhibits many immuno-modulatory properties and has been used clinically to treat several autoimmune disease. Currently, immunoglobulin is being investigated as an immuno-modulatory therapy in many neurological diseases. Neuropathic pain is choronic intractable pain syndrome, which has complex mechanisms, immuno-modulatory involved. Recently, intravenous immunoglobulin has significant antinocicetptive effect on neuropahtic pain patients, without any serious adverse reactions. It improves functional recovery, and quality of life. The mechanism may be blocking immunoglobulin binding with Fc receptor or neutralizing antibodies to reduce the damage of complement-mediated; may also reduce inflammatory cytokines in patients with neurological disease.

Key words: analgesic, immunoglobulin, immuno-modulatory, neuropathic pain

CLC Number:

R741

WANG Li-feng, ZHANG Zhi-yu, LI Zhen-zhen, LIANG Ying-xia. Research progress of therapy of intravenous immunoglobulin on neuropathic pain[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(2): 213-216.

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