Study on the mechanism of cytochrome P450 3A4

Abstract

Abstract: The cytochrome P450 (CYP) enzymes, involved in the metabolism of therapeutic drugs, are the major determinants of drug half-life. Among 57 human P450s, CYP3A4 is the most abundant and the most important because it metabolizes the majority of administered drugs. In this review we provide an overview on recent progress in the CYP3A4 research, such as basic structure, active site, mechanism of action, genetic phenotypes, probe substrate, drug metabolism and so on.

Key words: CYP3A4, gene polymorphism, mechanism of action, metabolism, probe

CLC Number:

R969.1

HUANG Wei, HU Xiao. Study on the mechanism of cytochrome P450 3A4[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(2): 223-229.

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