Shh, Gli1 gene expression and clinical significance of multiple myeloma

Abstract

Abstract: AIM: To investigate the expression of Shh and Gli1 gene of Hedgehog-Gli signaling pathway on multiple myeloma and its significance.METHODS: Detecting the Shh and Gli1 mRNA expression in 30 multiple myeloma patients and 20 non hematologic-malignancies patients by RT-PCR, and investigating relationships between Shh or Gli1 gene and clinical targets.RESULTS: Compared with the control group,the Shh and Gli1 mRNA expression in multiple myeloma patients were decreased significantly(P<0.01),which were higher in phase Ⅲ than in phaseⅠor Ⅱ (P<0.05) when staging by D-S and ISS.There is no obvious difference between group A and group B.There is positive correlation between Shh and LDH or β₂MG,but negative correlation between Shh and albumin or Hb.There is positive correlation between Gil1 and LDH, calcium ion,CRP or β₂MG, but negative correlation between Gil1 and albumin or Hb. As well,There is positive correlation between Shh and Gil1.CONCLUSION: Shh and Gil1 play a role in the development of multiple myeloma, which were maybe new locus in targeted therapy.

Key words: Hedgehog-Gli signaling pathway, multiple myeloma, Shh, Gli1

CLC Number:

R733.3

XU You-hai, WANG Xing-hong. Shh, Gli1 gene expression and clinical significance of multiple myeloma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(3): 309-313.

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