Research progress in effects of VEGF and MMP-9 on ischemic stroke

Abstract

Abstract: Ischemic stroke is one of the major diseases which cause serious damage to the human health. It has a high incidence, morbidity and mortality, brings heavy burden to the family even the social economy and the national quality of life. In recent years, vascular endothelial growth factor (VEGF) and serum matrix metalloproteinases 9 (MMP-9) in ischemic stroke become a new hot spot in the world. A series of studies shown that once the ischemic stroke happened, under the condition of ischemia and hypoxia, the expression level of VEGF and MMP-9 upregulated through hypoxic stimulus and inflammatory medium. VEGF and MMP-9 were also closely related to the nerve function defect degree and the infarction size, which participated in the development process of the ischemic stroke and angiogenesis, and might be a method to evaluate severity and prognosis with ischemic stroke.

Key words: ischemic stroke, VEGF, MMP-9, ischemia, angiogenesis

CLC Number:

R743

WAN Mei, ZHOU Zhi-ming. Research progress in effects of VEGF and MMP-9 on ischemic stroke[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(3): 344-348.

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