Abstract: AIM: To discuss the anti-tumor effect of centelase on lung cancer induced by A549.METHODS: The lung cancer naked mouse models were established by A549 tumor cell. The mouse were randomly divided into five groups: the normal control group, the model group, the high dose group of centelase, the middle dose group of centelase and the low dose group of centelase and continuously treated and given drugs for 21 d after modeling. Blood and tumors were collected and the tumor inhibition rate was calculated. The morphological changes of tumor cells were observed by HE staining. The levels of IL-2,TNF-α were determined by ELISA.RESULTS: Compared with the model group, centelase could inhibit tumor cell significantly, make part of the tumor cell necrosis, dissolution, disappear and increase the levels of IL-2、TNF-α significantly(P<0.01).CONCLUSION: Centelase shows its anti-tumor effect by increasing the levels of IL-2,TNF-α.

Key words: centelase, A549, IL-2, TNF-α