Progress in thrombomodulin researches

Abstract

Abstract: Thrombomodulin(TM)is expressed mainly in vascular endothelium. The injury on endothelium causes the abnormal expression of TM and secretion of TM into blood. Therefore, TM is accepted as the marker for endothelial injury and associated with the initiation and developments of many kinds of disease. The present review summarized the recent advances of TM on anti-inflammation, maintaining epithelial morphology, improving hematopathy and transplantation, and anti-tumor effects. These findings suggest that TM not only possess diagnostic and prognostic significance, but also become the important therapeutic target or agent for many kinds of diseases.

Key words: thrombomodulin, anti-inflammation, hematopathy, tumor

CLC Number:

R966

LI Chen-yu, SUN Xiao-hong, WANG li, LI Hua. Progress in thrombomodulin researches[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(4): 445-449.

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