Influence of GM1 on insulin-like growth factor-1 and prognosis of hypoxic-ischemic encephalopathy patients

Abstract

Abstract:

AIM: To study the influence of GM1 on insulin-like growth factor-1 and prognosis of hypoxic-ischemic encephalopathy (HIE) patients. METHODS: 86 cases of HIE patients were divided into control group(46 cases) and observation group (40 cases). Control group received conventional treatment, while observation group received GM1 therapy. IGF-1, nervous system function, oxidative stress contents 2 weeks' after treatment, rate of cerebral palsy, epilepsy, mental retardation and death after 6 months treatment were compared between the two groups. Correlation between IGF-1 and short and long term outcomes of HIE patients was further analyzed.RESULTS:After two weeks' treatment, serum IGF-1 level, SOD, GSH-Px contents and NGF of observation group were higher than that of control group, while serum nervous system function NSE, S-100β, CK-BB, NT-proBNP levels, serum ROS,NO,MDA contents were lower than that of control group. No direct correlation between IGF-1 content and nervous system function, oxidative stress index. CONCLUSION: GM1 can improve the content of IGF-1, and further optimize the short and long term treatment outcome of HIE patients.

Key words: HIE, GM1, IGF-1, neurological function, oxidative stress

CLC Number:

R742.8

FANG Sheng, WANG Lizhen. Influence of GM1 on insulin-like growth factor-1 and prognosis of hypoxic-ischemic encephalopathy patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(1): 72-76.

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