Clinical value of combined detection of amylase, lipase and procalcitonin in the diagnosis of children with acute pancreatitis

Abstract

Abstract:

AIM: To explore the diagnostic value of combined measurement of lipase (LIP) , amylase (AMY) and procalcitonin (PCT) in children with acute pancreatitis(AP). METHODS: Eighty-five children with AP (AP group) and eighty-five healthy children (control group) hospitalized in department of pediatrics of the First Affiliated Hospital of Xinxiang Medical University from January 2011 to December 2015 were included. The peripheral venous blood was collected at admission and thirty-six hours after development of disease to detect the levels of LIP, AMY and PCT, and LDH and CRP levels were also detected at the same time. The results were compared between the two groups．RESULTS: There was no statistically significant difference in age and proportion of gender between two groups; the average age of the children was 4 years old. At admission, the levels of LIP, AMY and PCT in serum in AP group were higher than those in control group (P<0.05). Serum LDH and CRP levels were also higher than those in control group with no statistical significance (P>0.05). Compared with the control group, the serum LIP, AMY, PCT, LDH and CRP levels were further increased in AP group 36 h after admission (P<0.05). CONCLUSION: Combined detection of LIP, AMY, PCT, LDH and CRP shows higher sensitivity, which is referential for the early diagnosis and exclusion of children AP, and it can be helpful for early treatment of children with AP.

Key words: acute pancreatitis, children, procalcitonin, lipase, amylase

CLC Number:

R576

ZHAO Zhiqiang, XI Zan, YAN Pengfei . Clinical value of combined detection of amylase, lipase and procalcitonin in the diagnosis of children with acute pancreatitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(11): 1265-1268.

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