Therapeutic effect of human umbilical cord-derived mesenchymal stem cells for severe knee osteoarthritis

Abstract

Abstract:

AIM: To explore the therapeutic effect of two methods of knee joint cavity injection in treating sodium hyaluronate and human umbilical cord-derived mesenchymal stem cells for severe knee osteoarthritis by evaluating pain degree, clinical effect, radiological change, and safety. METHODS: In this semi-blind parallelling study, 44 severe knee osteoarthritis patients were randomly divided into 3 groups. 16 patients in group A were injected with sodium hyaluronate 5 times individually. 15 patients in group B were injected with human umbilical cord-derived mesenchymal stem cells twice. 13 patients in group C were injected with human umbilical cord-derived mesenchymal stem cells 4 times. VAP scores, American Knee Society Knee scores, and Kellgren-Lawrence radiographic evaluation were evaluated. Follow-up were conducted 3, 6 and 12 months after treatment for recording clinical examination, evaluating observed indicators and safety assessment. Laboratory tests and X-ray examination of the knee were checked 6 and 12 months after treatment independently. RESULTS: VAP scores: significant difference were found in three groups before and 3, 6, 12 months after treatment; results showed that there were significant difference in group A 12 months after treatment comparing with group B and group C. AKS scores: significant difference were found in group B and group C before and 3, 6, 12 months after treatment; AKS Function: significant difference were found in group B and group C before and 3, 6, 12 months after treatment; Kellgren-Lawrence radiographic evaluation: no significant difference were found during the study. CONCLUSION: Comparing with sodium hyaluronate injection, the therapeutic effect of human umbilical cord-derived mesenchymal stem cells for severe knee osteoarthritis was more effective in relieving pain and improving joint function. Four times injections are better than two times injection.

Key words: osteoarthritis, human umbilical cord derived mesenchymal stem cells, sodium hyaluronate

CLC Number:

R684.3

YANG Xiaobing, JIANG Feng, ZHANG Fan, SHI Xingfen, LIU Limin, XU Zhiguo. Therapeutic effect of human umbilical cord-derived mesenchymal stem cells for severe knee osteoarthritis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(3): 305-311.

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