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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2018, Vol. 23 ›› Issue (10): 1116-1125.doi: 10.12092/j.issn.1009-2501.2018.10.006

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Clinical trial of multiple compound Chinese medicine injections in the treatment of mice with chemotherapy-related leukopenia

ZHANG Xiping1, ZHANG Xiang2, YANG Hongjian1, ZOU Dehong1, QIAO Enqi1, WANG Zhun3, HE Xiangming 1, YU Xingfei 1, ZHANG Ying 4, TANG Binbin 5   

  1. 1 Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang, China; 2 Department of Hematology, the First Affiliated Hospital of Medical College of Zhejiang University, Hangzhou 310006, Zhejiang, China; 3 Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang, China; 4 Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; 5 Second Outpatient Department of Traditional Chinese Internal Medicine, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, China
  • Received:2018-04-23 Revised:2018-08-26 Online:2018-10-26 Published:2018-10-25

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Abstract:

AIM: To investigate the effects of 5 commonly-used compound traditional Chinese medicine (TCM) injections and granulocyte-colony stimulating factor (G-CSF) in the treatment of chemotherapy-related leukopenia mice, as well as their effects on multiple organs and thymus of the mice.  METHODS: Cyclophosphamide intraperitoneal injection was used to prepare mice model with Chemotherapy-related leukopenia. The mice treated with G-CSF were taken as positive control, while the mice in each treatment group were given intraperitoneal injection of kang'ai, kushen, shenfu, shenmai and shengmai, respectively. The mice were killed the next day after drawing peripheral blood for routine blood test. Cardiac blood was taken to measure serum liver and kidney function indexes (ALT, AST, BUN and CR), while important organs (heart, liver, spleen, lung, kidney) and thymus were taken to calculate the corresponding organ index. RESULTS:Compared with the model group, the white blood cell (WBC) count of the mice in the five TCM-treated groups was significantly increased (P<0.01), which was lower than that of the G-CSF-treated group (P<0.05, P<0.01). In addition, G-CSF and 5 kinds of TCM injections can promote platelet at different levels (P<0.05, P<0.01). Compared with the model group, the level of serum AST was slightly increased in the kushen-treated group (P=0.036) and the shenfu-treated group (P=0.008). Serum ALT and renal function index were not significantly increased in each TCM-treated group, while the spleen index decreased (P<0.05 or P<0.01) and the lung index increased (P<0.01). In 5 TCM-treated groups, the liver cells of the mice showed different degrees of cellular degeneration, spot-like necrosis and inflammatory response, but the difference between the groups was not significant. Expect for the kushen-treated group, the liver pathology score of the other TCM-treated groups was significantly lower than that of the model group (P<0.05, P<0.01), among which the most significant was in the shengmai-treated group (P<0.01). CONCLUSION: All the 5 TCM injections can effectively treat chemotherapy-related leukopenia, which is weaker than G-CSF. Five TMC injections and G-CSF also have a certain platelet effect. In addition to kushen, the other 4 TMC injections may all have protective effects on liver. The effects of 5 TMC injections on other organs and thymus are not significant.

Key words: TCM injections, G-CSF, chemotherapy, leucopenia, neutropaenia

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