Effects of oxycodone hydrochloride controlled release tablets plus NB-UVB in the treatment of herpes zoster neuralgia

doi:10.12092/j.issn.1009-2501.2018.03.016

Abstract

Abstract:

AIM: To evaluate the curative effects of oxycodone hydrochloride controlled-release tablets plus NB-UVB in the treatment of herpes zoster neuralgia. METHODS: A prospective study method was adopted; one hundred and twenty cases of patients with herpes zoster treated by our hospital from September 2013 to February 2016 were selected and were equally divided into the observation group and control group according to the random-envelope principles. Both groups received antiviral treatment, and the control group was given NB-UVB therapy, while the observation group received oxycodone hydrochloride controlled release tablets combined with NB-UVB therapy; the treatment cycle was 14 days. RESULTS: The skin lesion regression time of the observation group was (6.18±1.05) d, which was significantly shorter than (7.93±1.36) d in the control group (P<0.05). The pain and skin lesions scores in the observation group after treatment were (2.33±1.38) points and (1.26±0.76) points, which were significantly lower than (4.46±1.93) points and (3.56±1.18) points of the control group (P<0.05), and that before treatment (P<0.05). There were no severe adverse reactions in the two groups during the treatment, and the nausea and vomiting, constipation, drowsiness, dizziness and other adverse reactions compared between the two groups showed no significant difference (P>0.05). CONCLUSION: Oxycodone hydrochloride controlled release tablets combined with NB-UVB in the treatment of herpes zoster neuralgia can effectively and safely relieve the pain and skin lesions so as to promote the patient's rehabilitation.

Key words: oxycodone hydrochloride controlled-release tablets, NB-UVB, herpes zoster, skin lesions, adverse reaction

CLC Number:

R752.1

XU Lili, WANG Yunfu, QUAN Bianrui. Effects of oxycodone hydrochloride controlled release tablets plus NB-UVB in the treatment of herpes zoster neuralgia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(3): 333-336.

References

［1］杨静,刘智慧,赵国利,等.老年患者带状疱疹后遗痛的临床特点和综合治疗［J］.中华老年多器官疾病杂志,2015,6(22):406-409.
［2］Singh S, Kumar P, Sharma VK. Cetirizine-induced urticaria masquerading as multiple drug intolerance syndrome［J］.Indian J Dermatol Venereol Leprol,2015,11(10):378-391.
［3］李碧磊,孙冲,徐迪荣,等.普瑞巴林联合盐酸羟考酮治疗带状疱疹后遗神经痛效果观察［J］.中国乡村医药,2016,23(1):9-10.
［4］郑昊龙,周晓虎,杜威,等.羟考酮缓释片联合普瑞巴林治疗中重度非癌性神经病理性疼痛临床观察［J］.中国疼痛医学杂志,2016,22(5):389-392.
［5］Truong Q, Veltri L, Kanate AS, et al. Impact of the duration of antiviral prophylaxis on rates of varicella-zoster virus reactivation disease in autologous hematopoietic cell transplantation recipients［J］.Ann Hematol,2014,93(4):677-682.
［6］董小瑜.半导体激光照射联合泛昔洛韦治疗带状疱疹临床疗效观察［J］.中国中西医结合皮肤性病学杂志,2014,13(2):107-109.
［7］Ford LB, Matz J, Hankinson T, et al. A comparison of fluticasone propionate nasal spray and cetirizine in ragweed fall seasonal allergic rhinitis［J］.Allergy Asthma Proc,2015,36(4):313-319.
［8］岳海龙,王丽昆,毕廷民,等.神经阻滞与窄谱中波紫外线治疗带状疱疹神经痛的疗效观察［J］.中国实用神经疾病杂志,2014,22(9):92-93.
［9］陈胜平,陈锦华,陈向齐,等.阿昔洛韦联合高能红光和窄谱中波紫外线治疗免疫功能下降带状疱疹患者的疗效观察［J］.实用皮肤病学杂志,2013,3(13):146-148.
［10］Preis M, Grother L, Axe P, et al. In-vitro and in-vivo evaluation of taste-masked cetirizine hydrochloride formulated in oral lyophilisates［J］.Int J Pharm,2015,491(1/2):8-16.
［11］张荣华,王海,戴锦艳,等.NB-UVB联合普瑞巴林治疗带状疱疹后遗神经痛的疗效［J］.江苏医药,2014,40(24):3046-3047.
［12］Liang L, Li X, Zhang G, et al.Pregabalin in the treatment of herpetic neuralgia: results of a multicenter Chinese study［J］.Pain Med,2015,16(1):160-167.
［13］刘瑞林.盐酸羟考酮控释片联合普瑞巴林治疗带状疱疹后神经痛的疗效和安全性分析［J］.海峡药学,2015,27(12):139-141.
［14］高爱莉,易敏,马少吟,等.普瑞巴林联合 NB-UVB 治疗老年带状疱疹后神经痛的临床疗效观察［J］.皮肤性病诊疗学杂志,2014,3(8):239-241.
［15］Achar A, Chakraborty PP, Bisai S, et al.Comparative study of clinical efficacy of amitriptyline and pregabalin in postherpetic neuralgia［J］.Acta Dermatovenerol Croat,2012,20(2):89-94.
［16］Gan EY, Tian EA, Tey HL.Management of herpes zoster and post-herpetic neuralgia［J］.Am J Clin Dermatol,2013,14(2):77-85.
［17］刘宁红,吴海玲.盐酸羟考酮缓释片联合加巴喷丁治疗老年重度癌痛的临床观察［J］.中国药物与临床,2015,15(9):1301-1303.
［18］魏亚东,杜宝林,师茸.普瑞巴林联合洛芬待因缓释片治疗老年带状疱疹后神经痛的临床疗效分析［J］.中国生化药物杂志,2015,11(8):155-158.
［19］Shibahara H, Ando A, Suzuki S, et al. Oxycodone and pregabalin using transdermal fentanyl patch provided relief of symptoms for postherpetic neuropathic pain in a patient with non-small cell lung cancer［J］.Gan Kagaku Ryoho,2011,38(10):1675-1677.
［20］魏辉明,麻伟青,杨云丽,等.GABAA受体对神经病理性痛大鼠海马长时程增强维持的影响［J］.中国临床药理学与治疗学,2016,21(11):1267-1270.

[1]	LI Xinyu, HUANG Xin. State of clinical application of meloxicam [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(2): 189-197.
[2]	YANG Mengjiao, YUAN Hao, ZHENG Ya, WANG Yuping, GUO Qinghong. Advances in the treatment of potassium-competitive acid blockers in reflux esophagitis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(10): 1190-1196.
[3]	HUANG Yiting, SHEN Aizong. Clinical research progress of afatinib therapy for lung cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(4): 474-480.
[4]	XING Kai, GONG Jinyu, LUO Jianquan. Advances on pharmacogenomics of diuretics-related adverse reactions [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(2): 204-212.
[5]	ZHANG Lu, LIN Liangmo, LIU Keke, HUANG Yamin, HUANG Xingxing, YANG Yongyu, XIAO Jian. Therapeutic drug monitoring and pharmacokinetics of new coronavirus pneumonia antiviral drugs [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(5): 566-575.
[6]	. Research progress of linezolid-induced lactic acidosis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(12): 1408-1413.
[7]	WANG Mengzhi, WEI Yuguang, HUANG Xiaoling. Analysis of rational usage of meropenem in our hospital [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(8): 937-941.
[8]	GUI Hua, CAO Shanshan, ZHAO Qiaoyun, WANG Peihong. Effects of climen associated with goserelin on serum hormone levels of laparoscopic surgery in patients with endometriosis after laparoscopic hysterectomy [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(5): 557-560.
[9]	WANG Shibiao, WANG Chengyi, WENG Bin, GUO Xiaofeng, LIN Hai. Comparison of the efficacy of non-invasive USCOM and milrinone in children with severe pneumonia and heart failure and its effect on brain natriuretic peptide levels [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(12): 1402-1407.
[10]	ZHANG Zhaowei, FANG Tianzi, LIU Jianxia. Study of the efficacy and safty of irinotecan combined with nedaplatin versus topotecan combined with nedaplatin in treatment of small lung cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(8): 943-947.
[11]	ZHOU Shuzhen, GAO Yunyun, XIE Jing, GAO Mengfei. Clinical trial of minocycline hydrochloride combined with vitapex paste in the treatment of persistent apical periodontitis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 170-173.
[12]	HU Hua, XIE Hai-tang, XU Zhe, PU Zhi-cheng, CHEN Qun, SUN Hua, ZHANG Xue-feng. Development of ^ADRCAS ——adverse drug reactions comprehensive analysis system [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(6): 712-716.
[13]	MENG Long, CHEN Yong-fei, ZHANG Jin-ping, FANG Yun. Glucocorticoid-induced gastrointestinal complications and prophylaxis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(5): 596-600.
[14]	DENG Dun, CHEN Li-qiu, ZHANG Wei-kang, YAN Hai-bo, WANG Zhao-hui, CHEN Xiao-yu, SHI Qi, WANG Yong-jun. Clinical efficacy of Yiqihuoxuezhuanggu Formula in PMO patients [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1383-1387.
[15]	LI Su-xia, YANG Xiao-lei, CHEN Su-xiu, LIU Jie-fan, QUAN Shi-chao. Efficacy and safety of gefitinib treated elded-patients with advanced non-small cell lung cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1410-1413.