Abstract: The liver is one of the most important organs in human body, which participates in metabolism and detoxification. The liver is easily affected by various drugs and their metabolites. Drug-induced liver injury, also known as drug-induced liver disease, refers to the liver damage or allergic reaction to liver caused by drugs and their metabolites. MicroRNA (miRNA) is a kind of small non-coding RNA, which plays an important regulatory role in many diseases. In this review, the effects and mechanisms of miRNAs in drug-induced liver injury were summarized.

Key words: drug-induced liver injury, microRNA, regulation function and mechanism, drug target