Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2026, Vol. 31 ›› Issue (4): 551-560.doi: 10.12092/j.issn.1009-2501.2026.04.015
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Jieyu ZHANG, Yina WENG, Fei CAO(
)
Received:2025-01-05
Revised:2025-08-15
Online:2026-04-26
Published:2026-04-30
Contact:
Fei CAO
E-mail:kongzhongchenke@126.com
CLC Number:
Jieyu ZHANG, Yina WENG, Fei CAO. microRNAs expression profile changes in patients with Parkinson's disease and prospects for potential diagnosis and treatment[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(4): 551-560.
| 作者 | 样本量 | 样本来源 | miRNAs | 相对 表达量 | |
| PD组 | 对照组 | ||||
| Martins et al.[ | 19 | 13 | PBMCs | miR-335, miR-374a/b, miR-199, miR-126, miR-151-5p, miR-29b/c, miR-147, miR-28-5p, miR-30b/c, miR-301a, miR-26a | 下降 |
| Zhuang et al.[ | 120 | 120 | 血浆、脑脊液 | miR-125b | 下降 |
| Pavelka et al.[ | 387 | 416 | 血浆 | miR-145-5p, miR-151a-3p, miR-145-3p, miR-130a-3p, miR- | 升高 |
| Li et al.[ | 53 | 60 | 血浆 | miR-10b-5p, miR-150-5p, miR-342-3p, miR-186-5p, miR-192-5p,miR-361-3p, miR-155-5p, miR- | 下降 |
| miR-4433b-5p, miR-335-3p, miR-130b-5p, miR-766-3p, miR-744-5p, miR- | 升高 | ||||
| Qiu et al.[ | 23 | 30 | 血浆 | miR-1976, miR-153, miR-103a, miR-29q | 升高 |
| miR-210, miR-375, miR-146a, miR-101a | 下降 | ||||
| Rai et al.[ | 16 | 16 | 血浆 | miR- miR-203b-5p, miR-205-5p, miR-708-3p, miR-106b-3p, miR-23b-3p, miR-203a-3p | 升高 |
| miR-143-5p, miR- | 下降 | ||||
| Chen et al.[ | 75 | 73 | 血浆 | miR-153, miR-223 | 下降 |
| Jang et al.[ | 5 | 20 | 血浆 | miR-195-5p, miR-495-3p, miR-23b-3p, miR-323a-3p, miR-30c-2-3p, miR-27a-3p | 升高 |
| Zhang et al.[ | 13 | 27 | 脑脊液 | miR-124 | 下降 |
| Tan et al.[ | 7 | 4 | 脑脊液 | miR-486-5p, miR-122-5p, miR-451a, miR-423-5p, let-7b-5p, miR-151a-3p, miR-320a, miR-574-5p, miR-206, miR-204-5p, miR- | 升高 |
| Tong et al.[ | 209 | 50 | 血清、脑脊液 | miR-151a-5p, miR-24, miR-485-5p, miR-331-5p, miR-214 | 升高 |
| miR-331-3p, miR-485-3p | 下降 | ||||
| Wu et al.[ | 50 | 50 | 血清 | miR-19b-3p | 下降 |
| Wan et al.[ | 51 | 51 | 血清 | miR-218-5p, miR-320-5p | 下降 |
| Aguilar et al.[ | 60 | 40 | 血清 | miR-26b-5p, miR-25-3p, miR-191-5p, miR-330, miR- | 升高 |
| Lin et al.[ | 92 | 64 | 血清 | miR*485-3p | 下降 |
| Soto et al.[ | 20 | 40 | 血清 | miR-22-3p, miR-16-5p, miR-19b-3p | 下降 |
| Manna et al.[ | 40 | 33 | 血清 | miR-22-3p, miR-223-5p | 升高 |
| Citterio et al.[ | 45 | 39 | 血清 | miR-7-1-5p, miR-223-3p | 升高 |
| Guévremont et al.[ | 287 | 168 | 血清 | miR-24-3p | 升高 |
| Cressatti et al.[ | 83 | 77 | 唾液 | miR-223, miR-153 | 下降 |
| Chen et al.[ | 30 | 330 | 唾液 | miR-874, miR-145-3p | 升高 |
Table 1 Abnormal expression of miRNAs in patients with Parkinson's disease
| 作者 | 样本量 | 样本来源 | miRNAs | 相对 表达量 | |
| PD组 | 对照组 | ||||
| Martins et al.[ | 19 | 13 | PBMCs | miR-335, miR-374a/b, miR-199, miR-126, miR-151-5p, miR-29b/c, miR-147, miR-28-5p, miR-30b/c, miR-301a, miR-26a | 下降 |
| Zhuang et al.[ | 120 | 120 | 血浆、脑脊液 | miR-125b | 下降 |
| Pavelka et al.[ | 387 | 416 | 血浆 | miR-145-5p, miR-151a-3p, miR-145-3p, miR-130a-3p, miR- | 升高 |
| Li et al.[ | 53 | 60 | 血浆 | miR-10b-5p, miR-150-5p, miR-342-3p, miR-186-5p, miR-192-5p,miR-361-3p, miR-155-5p, miR- | 下降 |
| miR-4433b-5p, miR-335-3p, miR-130b-5p, miR-766-3p, miR-744-5p, miR- | 升高 | ||||
| Qiu et al.[ | 23 | 30 | 血浆 | miR-1976, miR-153, miR-103a, miR-29q | 升高 |
| miR-210, miR-375, miR-146a, miR-101a | 下降 | ||||
| Rai et al.[ | 16 | 16 | 血浆 | miR- miR-203b-5p, miR-205-5p, miR-708-3p, miR-106b-3p, miR-23b-3p, miR-203a-3p | 升高 |
| miR-143-5p, miR- | 下降 | ||||
| Chen et al.[ | 75 | 73 | 血浆 | miR-153, miR-223 | 下降 |
| Jang et al.[ | 5 | 20 | 血浆 | miR-195-5p, miR-495-3p, miR-23b-3p, miR-323a-3p, miR-30c-2-3p, miR-27a-3p | 升高 |
| Zhang et al.[ | 13 | 27 | 脑脊液 | miR-124 | 下降 |
| Tan et al.[ | 7 | 4 | 脑脊液 | miR-486-5p, miR-122-5p, miR-451a, miR-423-5p, let-7b-5p, miR-151a-3p, miR-320a, miR-574-5p, miR-206, miR-204-5p, miR- | 升高 |
| Tong et al.[ | 209 | 50 | 血清、脑脊液 | miR-151a-5p, miR-24, miR-485-5p, miR-331-5p, miR-214 | 升高 |
| miR-331-3p, miR-485-3p | 下降 | ||||
| Wu et al.[ | 50 | 50 | 血清 | miR-19b-3p | 下降 |
| Wan et al.[ | 51 | 51 | 血清 | miR-218-5p, miR-320-5p | 下降 |
| Aguilar et al.[ | 60 | 40 | 血清 | miR-26b-5p, miR-25-3p, miR-191-5p, miR-330, miR- | 升高 |
| Lin et al.[ | 92 | 64 | 血清 | miR*485-3p | 下降 |
| Soto et al.[ | 20 | 40 | 血清 | miR-22-3p, miR-16-5p, miR-19b-3p | 下降 |
| Manna et al.[ | 40 | 33 | 血清 | miR-22-3p, miR-223-5p | 升高 |
| Citterio et al.[ | 45 | 39 | 血清 | miR-7-1-5p, miR-223-3p | 升高 |
| Guévremont et al.[ | 287 | 168 | 血清 | miR-24-3p | 升高 |
| Cressatti et al.[ | 83 | 77 | 唾液 | miR-223, miR-153 | 下降 |
| Chen et al.[ | 30 | 330 | 唾液 | miR-874, miR-145-3p | 升高 |
| 作者 | miRNAs | 模型 | 治疗方法 | 功能 |
| Wang et al.[ | miR-205 | SH-SY5Y细胞 | miR-205模拟物 | 抑制 LRRK2表达 |
| Fan et al.[ | miR-153 | PD小鼠 | miR-153模拟物 | 抑制α-突触核蛋白表达 |
| He et al.[ | miR-137 | PD小鼠 | miR-137模拟物 | 抑制α-突触核蛋白表达 |
| Zhou et al.[ | miR-7 | PD小鼠 | miR-7模拟物 | 抑制NLRP3表达 |
| Li et al.[ | miR-30e | PD小鼠 | miR-30e模拟物 | 抑制NLRP3表达 |
| Zeng et al.[ | miR-135b | SH-SY5Y、PC-12细胞 | miR-135b模拟物 | 抑制NLRP3表达 |
| Hu et al.[ | miR-425 | PD小鼠 | miR-425模拟物 | 抑制RIPK1表达 |
| Wu et al.[ | miR-543-3p | PD小鼠 | miR-543-3p模拟物 | 抑制α-突触核蛋白表达 |
| Li et al.[ | miR-150 | BV2细胞 | miR-150模拟物 | 抑制促炎细胞因子表达 |
| Wang et al.[ | miR-29c-3p | PD小鼠 | miR-29c-3p模拟物 | 激活NFAT5 |
| He et al.[ | miR-100a-5p | MN9D细胞 | miR-100a-5p模拟物 | 激活Nox4/ROS/Nrf2信号通路 |
| Esfahani et al.[ | miR-101-3p | SH-SY5Y细胞 | miR-101-3p模拟物 | 促进PGC1α表达 |
| Yao et al.[ | miR-221 | PD小鼠 | miR-221模拟物 | 抑制Bim/Bax/caspase-3信号通路 |
| Esteves et al.[ | miR-124-3p | PD小鼠 | miR-124-3p模拟物 | 减少多巴胺能神经元死亡 |
| Almeida et al.[ | miR-134 | PD大鼠 | miR-134抑制剂 | 减弱纹状体多巴胺能神经元损伤 |
| Vallelunga et al.[ | miR-30c-5p | PD小鼠 | miR-30c-5p抑制剂 | 上调ATG5表达 |
| Lv et al.[ | miR-3473b | PD小鼠 | miR-3473b抑制剂 | 增加TREM2和ULK1的表达 |
| Dong et al.[ | miR-421 | PD小鼠 | miR-421抑制剂 | 抑制调节MEF2D的表达 |
| Kaurani et al.[ | miR-129-5p | PD小鼠 | miR-129-5p抑制剂 | 抑制谷氨酸转运蛋白表达 |
Table 2 miRNAs and treatment of Parkinson's disease
| 作者 | miRNAs | 模型 | 治疗方法 | 功能 |
| Wang et al.[ | miR-205 | SH-SY5Y细胞 | miR-205模拟物 | 抑制 LRRK2表达 |
| Fan et al.[ | miR-153 | PD小鼠 | miR-153模拟物 | 抑制α-突触核蛋白表达 |
| He et al.[ | miR-137 | PD小鼠 | miR-137模拟物 | 抑制α-突触核蛋白表达 |
| Zhou et al.[ | miR-7 | PD小鼠 | miR-7模拟物 | 抑制NLRP3表达 |
| Li et al.[ | miR-30e | PD小鼠 | miR-30e模拟物 | 抑制NLRP3表达 |
| Zeng et al.[ | miR-135b | SH-SY5Y、PC-12细胞 | miR-135b模拟物 | 抑制NLRP3表达 |
| Hu et al.[ | miR-425 | PD小鼠 | miR-425模拟物 | 抑制RIPK1表达 |
| Wu et al.[ | miR-543-3p | PD小鼠 | miR-543-3p模拟物 | 抑制α-突触核蛋白表达 |
| Li et al.[ | miR-150 | BV2细胞 | miR-150模拟物 | 抑制促炎细胞因子表达 |
| Wang et al.[ | miR-29c-3p | PD小鼠 | miR-29c-3p模拟物 | 激活NFAT5 |
| He et al.[ | miR-100a-5p | MN9D细胞 | miR-100a-5p模拟物 | 激活Nox4/ROS/Nrf2信号通路 |
| Esfahani et al.[ | miR-101-3p | SH-SY5Y细胞 | miR-101-3p模拟物 | 促进PGC1α表达 |
| Yao et al.[ | miR-221 | PD小鼠 | miR-221模拟物 | 抑制Bim/Bax/caspase-3信号通路 |
| Esteves et al.[ | miR-124-3p | PD小鼠 | miR-124-3p模拟物 | 减少多巴胺能神经元死亡 |
| Almeida et al.[ | miR-134 | PD大鼠 | miR-134抑制剂 | 减弱纹状体多巴胺能神经元损伤 |
| Vallelunga et al.[ | miR-30c-5p | PD小鼠 | miR-30c-5p抑制剂 | 上调ATG5表达 |
| Lv et al.[ | miR-3473b | PD小鼠 | miR-3473b抑制剂 | 增加TREM2和ULK1的表达 |
| Dong et al.[ | miR-421 | PD小鼠 | miR-421抑制剂 | 抑制调节MEF2D的表达 |
| Kaurani et al.[ | miR-129-5p | PD小鼠 | miR-129-5p抑制剂 | 抑制谷氨酸转运蛋白表达 |
Fig.1 Mechanism of action of miRNA inhibitors This figure illustrates three main strategies for inhibiting miRNA function: A: anti-miRNA Oligonucleotides (AMOs) that directly bind to and degrade mature miRNAs; B: antagomirs, which are cholesterol-conjugated AMOs for enhanced in vivo stability and delivery.
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