Defined as a common gynecologic endocrine disease, endometriosis is characterized by the presence of endometrium outside of the uterus cavity, affecting about 10% to 15% of reproductive-aged women worldwide.Moreover, Asian women tend to have a nine-fold increased risk of endometriosis compared with their white counterparts in Europe and the United States. Endometriosis not only causes chronic pelvic pain, dysmenorrhea, painful sex and other pain symptoms, but also leads to infertility, pushing the patients into a state of fatigue, high sensitivity and anxiety, thus reducing their quality of life. As the aging of Chinese population intensifies and the women's childbearing age delays, it is highly urgent to find solutions to those gynecological endocrine diseases such as endometriosis, which hamper women's fertility. In recent years, studies have shown that patients with endometriosis have abnormal serum lipid metabolism and an increased risk of cardiovascular diseases. At the same time, as a type of cholesterol-lowering drug, statins can inhibit the progression of endometriosis at the cellular and animal levels. Also, a few clinical studies have exhibited that statins exert a positive effect on the treatment of endometriosis. Therefore, this article aims to review the researches regarding the relationship between endometriosis and the cardiovascular disease, as well as the research progress of statin therapy on endometriosis based on the level of cells, animals and human beings.