Effect of baicalin on airway remodeling of bronchial asthma

Abstract

Abstract:

AIM: To explore the effect and mechanism of baicalin on the airway remodeling of bronchial asthma. METHODS: Animal models of airway remodeling in asthmatic rats were induced by egg albumen (OVA). After the treatment of Baicalin, expressions of TGF-β1, p-ERK1/2 and α-SMA in the lung tissue of rats were detected by immunohistochemical method, and the level of p-ERK1/2 mRNA in the airway smooth muscle (ASM) was detected by RT-PCR. RESULTS:Expressions of p-ERK1/2, α-SMA and TGF-β1 were significantly increased in the model group, which were all higher than those of dexamethasone group, baicalin high dose group and low dose group (P<0.05 or P<0.01). CONCLUSION: Baicalin can decrease the expression of TGF-β1, α-SMA, affect the ERK signal pathways, down regulate the content of p-ERK1/2 mRNA , thereby reducing airway inflammation and delaying airway remodeling.

Key words: baicalin, airway remodeling, ERK signal pathways, TGF-β1, α-SMA

CLC Number:

R965.2

HAN Chao, YANG Liu, ZHANG Qiuling, PAN Jinqiang, XU Jun. Effect of baicalin on airway remodeling of bronchial asthma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(7): 749-754.

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