Abstract:

AIM: To study the effect of Shenfu injection on the quality of life and immune function in patients with breast cancer after chemotherapy.  METHODS: A total of 150 patients with breast cancer who received chemotherapy in our hospital from Dec.2016 to Dec.2017 were selected and randomly divided into the study group and the control group according to the random number table method. The control group was given conventional chemotherapy; the study group received extra Shenfu injection treatment on the basis of the control group. After 6 courses of chemotherapy, the clinical efficacy of the two groups was compared. The T cell subgroup, NK cell level, immunoglobulin level and the quality of life of the two groups were analyzed before and after chemotherapy and the occurrence of adverse reactions was observed. RESULTS: The total effective rate of the study group was 96%, which was significantly higher than that of the control group (86.67%) (P<0.05). Before chemotherapy, there was no significant difference in the levels of CD3+, CD4+, CD8+, CD4+/CD8+ and NK cells between the two groups (P>0.05). After chemotherapy, the level of CD3+, CD4+, CD4+/CD8+ and NK cells in the two groups increased, and the increase of the study group was higher than that of the control group. The level of CD8+ decreased and the decrease of the study group was lower than the control group. The two groups were significantly different (P<0.05). After chemotherapy, the lgG, lgA and lgM level of the two groups decreased, and the study group decreased more than the control group (P<0.05). After chemotherapy, the score of somatic function in the functional subscale of the study group was significantly higher than that of the control group. The scores of fatigue, nausea, vomiting and pain in the symptom subscale were significantly lower than those of the control group (P<0.05). The total adverse reaction rate in the study group was 4%, which was significantly lower than that in the control group (14.67%). There was a significant difference between the two groups (P<0.05). CONCLUSION: Shenfu injection can effectively improve the immune function of patients with breast cancer after chemotherapy, and improve the quality of life after operation. The clinical effect is remarkable and worthy of clinical application.

Key words: Shenfu injection, breast cancer, chemotherapy, quality of life, immune function