Research progress on the mechanism and treatment of pelvic organ prolapse

doi:10.12092/j.issn.1009-2501.2020.05.018

Abstract

Abstract: Pelvic organ prolapse (POP) is caused by a variety of causes, such as weak pelvic floor support system, abnormal location of female reproductive system and adjacent organs, uterine prolapse, anterior and posterior vaginal wall prolapse and other clinical diseases. In this paper, the epidemiology, etiology and current treatment of the disease were summarized, and the basic pathogenesis and the application prospect of mesenchymal stem cells (MSCs) in the disease were described in detail.

Key words: pelvic organ prolapse, mesenchymal stem cells, pathogenesis, treatment

CLC Number:

R711.2

ZHOU Yiwen, PING Yi. Research progress on the mechanism and treatment of pelvic organ prolapse[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(5): 595-600.

References

[1]Hendrix Sl, Clark A, Nygaard I, et al. Pelvic organ prolapse in the Women's Health Initiative: gravity and gravidity [J]. Am J Obstet Gynecol, 2002, 186(6): 1160-1166.
[2]Weber Am, Abrams P, Brubaker L, et al. The standardization of terminology for researchers in female pelvic floor disorders [J]. Int Urogynecol J, 2001, 12(3): 178-186.
[3]Bradley Cs, Zimmerman Mb, Qi Y, et al. Natural history of pelvic organ prolapse in postmenopausal women [J]. Obstet Gynecol, 2007, 109(4): 848-854.
[4]Islam RM, Oldroyd J, Rana J, et al. Prevalence of symptomatic pelvic floor disorders in community-dwelling women in low and middle-income countries: a systematic review and meta-analysis [J]. Int Urogynecol J, 2019. 10.1007/s00192-019-03992.
[5]李志毅. 中国城市地区女性盆腔器官脱垂临床流行病学调查 [J]. 中华医学杂志, 2019, 99(11): 857-861.
[6]丁峰. 厦门社区女性盆底功能障碍性疾病流行病学研究 [D]. 福建医科大学, 2011.
[7]陈聪. 温州女性盆底功能障碍性疾病流行病学研究 [J]. 温州医科大学学报, 2016, 46(3): 194-198.
[8]刘苗. 太原市女性盆腔器官脱垂流行病学调查及中医体质类型分析 [D]. 山西中医药大学, 2017.
[9]Kinman Cl, Lemieux CA, Agrawal A, et al. The relationship between age and pelvic organ prolapse bother [J]. Int Urogynecol J, 2017, 28(5): 751-755.
[10]Allen-Brady K, Norton Pa, Jolyn Hill A, et al. Risk of pelvic organ prolapse treatment based on extended family history [J]. Am J Obstet Gynecol, 2020. https://doi.org/10.1016/j.ajog.2019.12.271.
[11]Shah SM, Sultan Ah, Thakar R. The history and evolution of pessaries for pelvic organ prolapse [J]. Int Urogynecol J Pelvic Floor Dysfunct, 2006, 17(2): 170-175.
[12]Rantell A. Vaginal pessaries for pelvic organ prolapse and their impact on sexual function [J]. Sex Med Rev, 2019, 7(4): 597-603.
[13]Lone F, Thakar R, Sultan AH, et al. A 5-year prospective study of vaginal pessary use for pelvic organ prolapse [J]. Int J Gynaecol Obstet, 2011, 114(1): 56-59.
[14]Wu YM, Mcinnes N, Leong Y. Pelvic floor muscle training versus watchful waiting and pelvic floor disorders in postpartum women: A systematic review and meta-analysis [J]. Female Pelvic Med Reconstr Surg, 2018, 24(2): 142-149.
[15]Ahadi T, Taghvadoost N, Aminimoghaddam S, et al. Efficacy of biofeedback on quality of life in stages I and II pelvic organ prolapse: A Pilot study [J]. Eur J Obstet Gynecol Reprod Biol, 2017, 215: 241-246.
[16]Maher C, Feiner B, Baessler K, et al. Surgical management of pelvic organ prolapse in women [J]. Cochrane Database Syst Rev, 2013, 30(4): CD004014.
[17]Altman D, Väyrynen T, Engh ME, et al. Anterior colporrhaphy versus transvaginal mesh for pelvic-organ prolapse [J]. N Engl J Med, 2011, 364(19): 1826-1836.
[18]Heneghan CJ, Goldacre B, Onakpoya I, et al. Trials of transvaginal mesh devices for pelvic organ prolapse: a systematic database review of the US FDA approval process [J]. BMJ Open, 2017, 7(12): e017125.
[19]Wein AJ. Re: Implications of the FDA statement on transvaginal placement of mesh: the aftermath [J]. J Urol, 2015, 193(2): 606-607.
[20]Veit-Rubin N, Cartwright R, Singh Au, et al. Association between joint hypermobility and pelvic organ prolapse in women: a systematic review and meta-analysis [J]. Int Urogynecol J, 2016, 27(10): 1469-1478.
[21]Freitas-Rodríguez S, Folgueras Ar, Lòpez-Otín C. The role of matrix metalloproteinases in aging: Tissue remodeling and beyond [J]. Biochim Biophys Acta Mol Cell Res, 2017, 1864: 2015-2025.
[22]Dökmeci F, Teksen F, Cetinkayase, et al. Expressions of homeobox, collagen and estrogen genes in women with uterine prolapse [J]. Eur J Obstet Gynecol Reprod Biol, 2019, 233: 26-29.
[23]Esra NT, Nadiye K, Gonca YY, et al. The role of ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of uterosacral and cardinal ligaments in the etiopathogenesis of pelvic organ prolapse among women without stress urinary incontinence [J]. Eur J Obstet Gynecol Reprod Biol, 2018, 231: 158-163.
[24]Salman Mc, Ozyuncu O, Sargon Mf, et al. Light and electron microscopic evaluation of cardinal ligaments in women with or without uterine prolapse [J]. Int Urogynecol J, 2010, 21(2): 235-239.
[25]Antonella V, Simona P, Anna G, et al. Immunolocalization of advanced glycation end products, mitogen activated protein kinases, and transforming growth factor-β/Smads in pelvic organ prolapse [J]. J Histochem Cytochem, 2018, 22155418772798.
[26]Han L, Wang L, Wang Q, et al. Association between pelvic organ prolapse and stress urinary incontinence with collagen [J]. Exp Ther Med, 2014, 7(5): 1337-1341.
[27]Zeng C, Liu J, Wang H, et al. Correlation between autophagy and collagen deposition in patients with pelvic organ prolapse [J]. Female Pelvic Med Reconstr Surg, 2017, 24(3): 213-221.
[28]Clark DA, Coker R. Transforming growth factor-beta (TGF-beta) [J]. Int J Biochem Cell Biol, 1998, 30(3): 293-298.
[29]Liu C, Wang Y, Li Bs, et al. Role of transforming growth factor β-1 in the pathogenesis of pelvic organ prolapse: A potential therapeutic target [J]. Int J Mol Med, 2017, 40(2): 347-356.
[30]Itoh N, Ornitz Dm. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease [J]. J Biochem 2011, 149(2): 121-130.
[31]Koo Hy, El-Baz Lm, House S, et al. Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation [J]. J Pathol, 2018, 246(1): 54-66.
[32]韩晓瑾. 人子宫内膜间充质干细胞的分离、鉴定及生长因子对其向韧带成纤维细胞分化作用研究 [D]. 山西医科大学, 2019.
[33]Caplan AI. Mesenchymal stem cells [J]. J Orthop Res, 1991, 9(5): 641-650.
[34]Zhao B, Liang LL, Yan JG, et al. Effect of mechanical stretch on the expressions of elastin, LOX and Fibulin-5 in rat BMSCs with ligament fibroblasts co-culture [J]. Mol Biol Rep, 2012, 39(5): 6077-6085.
[35]贾双双, 李伟阳, 刘欣, 等. 转化生长因子- β1 通过产生活性氧诱导骨髓间充质干细胞分化为肌成纤维细胞 [J]. 北京大学学报(医学版), 2015, 5: 41.
[36]Ofra Ben Menachem-Zidon, Michal Gropp, Etti Ben Shushan, et al. Systemically transplanted mesenchymal stem cells induce vascular-like structure formation in a rat model of vaginal injury [J]. PLoS One, 2019, 14(6): e0218081.
[37]Arsalan S, Audrey C, Luis RM, et al. Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro [J]. Stem Cells Dev, 2015, 24(14): 1635-1647.
[38]Tao C, Gao SY, Yi H, et al. Experimental study of human amniotic mesenchymal stem cell exosome promoting fibroblasts migration through microRNA-135a [J]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2020, 34(2): 234-239.
[39]Enea D, Cecconi S, Calcagno S, et al. Single-stage cartilage repair in the knee with microfracture covered with a resorbable polymer-based matrix and autologous bone marrow concentrate [J]. The Knee, 2013, 20(6): 562-569.
[40]魏兆明, 江文胜, 高艺, 等. 脂肪间充质干细胞的生物学特性及潜在临床应用 [J]. 中国临床药理学与治疗学, 2019, 24(1): 116-120.
[41]Liu X, Wang S, Wu S, et al. Exosomes secreted by adipose-derived mesenchymal stem cells regulate type I collagen metabolism in fibroblasts from women with stress urinary incontinence [J]. Stem Cell Res Ther, 2018, 9(1): 159.
[42]Naside M, Christopher JH, Christopher RC, et al. Oestradiol-releasing biodegradable mesh stimulates collagen production and angiogenesis: An approach to improving biomaterial integration in pelvic floor repair [J]. Eur Urol Focus, 2019, 5(2): 280-289.
[43]Man-Jung H, Mei-Chin W, Ying-Ting H, et al. Fascia tissue engineering with human adipose-derived stem cells in a murine model: Implications for pelvic floor reconstruction [J]. J Formos Med Assoc, 2014, 113(10): 704-715.
[44]Ulrich D, Edwards Sl, Su K, et al. Human endometrial mesenchymal stem cells modulate the tissue response and mechanical behavior of polyamide mesh implants for pelvic organ prolapse repair [J]. Tissue Eng Part A, 2014, 20: 785-798.
[45]Emmerson S, Mukherjee S, Melendez-Munoz J, et al. Composite mesh design for delivery of autologous mesenchymal stem cells influences mesh integration, exposure and biocompatibility in an ovine model of pelvic organ prolapse [J]. Biomaterials, 2019, 225: 119495.