Abstract: AIM: To explore the effects of simvastatin and clopidogrel on high sensitivity C-reactive protein and blood lipids in patients with acute coronary syndrome. METHODS: 67 cases with acute coronary syndrome were randomly divided into intervention group (35 cases) and control group (32 cases).Two groups received the same conventional treatment, in addition, the intervention group was treated with simvastatin and clopidogrel, the levels of high sensitivity C-reactive protein and blood lipids were detected before and six week after treatment. RESULTS: The high sensitivity C-reactive protein and blood lipids levels of patients were significantly decreased in intervention group, compared with control group (P＜0.05). CONCLUSION: Treatment with simvastatin and clopidogrel not only decreases the blood lipids levels but also has the best effects on lowering high sensitivity C-reactive protein in patients with acute coronary syndrome.

Key words: Acute coronary syndrome, Simvastatin, Clopidogrel, High sensitivity C-reactive protein, Blood lipids