Research progress of miRNA in diabetes

Abstract

Abstract: The discovery hundreds of small RNA molecules, called microRNA, with the potential to modulate the expression of the majority of the protein-coding genes has revolutionized in the diabetes field. Moreover, alterations in the level or function of microRNA are associated with an increasing number of diseases. We present evidence for the involvement of microRNA in diabetes mellitus, by outlining the contribution of these microRNA molecules in the control of pancreatic β-cell functions and by reviewing recent studies reporting changes in microRNA expression in tissues. MicroRNA holds great potential as therapeutic targets. In this article, the researches of miRNA in diabetes and their potentialfor molecular therapy were summarized.

Key words: miRNA, Diabetes, Gene expression, Pancreatic islet, RNA interference

CLC Number:

R968

GONG Zhi-cheng, HUANG Qiong, LIU Zhao-qian. Research progress of miRNA in diabetes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(2): 214-218.

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