Recent research progress of eIF3 in biological function

Abstract

Abstract: eIF3a is the largest subunit of mammalian eukaryotic initiation factor 3 (eIF3). It has been shown by many research that eIF3a plays an essential role in regulating the initiation of mRNA translation and protein translation in mammalian cells as well as yeast cells.Additionally, eIF3a involves in cell cycle regulation, which also influents cell proliferation and differentiation greatly. There is a close relationship between eIF3a and tumor progression, development, prognosis and chemotherapeutic efficacy, moreover the genetic polymorphisms of eIF3a associates with susceptibility of carcinoma. This review summarizes the research progress of eIF3a biological functions in recent years.

Key words: eIF3a, Translation, Cell cycle, Proliferation and differentiation, Carcinoma

CLC Number:

R965.2

XU Xiao-jing, ZHOU Hong-hao, LIU Zhao-qian. Recent research progress of eIF3 in biological function[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(2): 219-224.

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