Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2010, Vol. 15 ›› Issue (2): 225-232.
Previous Articles Next Articles
SHANG Li-li1, SUN Jian-guo1, XIE Hai-tang2, WANG Guang-ji1
Received:
2009-12-07
Revised:
2010-01-11
Online:
2010-02-26
Published:
2020-09-18
CLC Number:
SHANG Li-li, SUN Jian-guo, XIE Hai-tang, WANG Guang-ji. Saponins in tumor therapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(2): 225-232.
[1] Vincken JP, Heng L, Groot A, et al. Saponins, classification and occurrence in the plant kingdom[J]. Phytochemistry,2007,68(3): 275-297. [2] Guclu-Ustundag O, Mazza G. Saponins: properties, applications and processing[J]. Crit Rev Food Sci Nutr, 2007,47(3): 231-258. [3] Ebbesen P, Dalsgaard K, Madsen M. Prolonged survival of AKR mice treated with the saponin adjuvant Quil A[J]. Acta Pathol Microbiol Scand A, 1976,84(4): 358-360. [4] Yu LJ, Ma RD, Wang YQ, et al. Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet[J]. Int J Cancer, 1992,50(4): 635-638. [5] Ma R, Song G, You W, et al.Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin[J]. Cancer Chemother Pharmacol, 2008,62(4): 559-568. [6] 王鑫,郑玉林,李克,等. 人参皂苷Rg3对人肺鳞癌细胞VEGF及KDR表达的影响[J]. 中药材, 2009,11: 1708-1710. [7] Kumar A, Kumar M, Park TY, et al. Molecular mechanisms of ginsenoside Rp1-mediated growth arrest and apoptosis[J]. Int J Mol Med, 2009,24(3): 381-386. [8] Kim SY, Kim DH, Han SJ, et al. Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells[J]. Biochem Pharmacol, 2007,74(11): 1642-1651. [9] Park TY, Park MH, Shin WC, et al. Anti-metastatic potential of ginsenoside Rp1, a novel ginsenoside derivative[J]. Biol Pharm Bull, 2008,31(9): 1802-1805. [10] Choi K, Choi C. Proapoptotic ginsenosides compound K and Rh enhance fas-induced cell death of human astrocytoma cells through distinct apoptotic signaling pathways[J]. Cancer Res Treat, 2009,41(1):36-44. [11] Kang JH, Han IH, Sung MK, et al. Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2[J]. Cancer Lett, 2008,261(1): 84-92. [12] Liu MJ, Wang Z, Ju Y, et al. The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines[J]. Biol Pharm Bull, 2004,27(7): 1059-1065. [13] Raju J, Bird RP. Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells[J]. Cancer Lett, 2007,255(2): 194-204. [14] 苏赞妍, 霍木兰. 薯蓣皂苷元诱导人卵巢癌细胞Ho-8910凋亡及对Survivin基因表达的影响[J]. 中国医师杂志, 2006,8(9): 1161-1163. [15] Shyu KG, Tsai SC, Wang BW, et al. Saikosaponin C induces endothelial cells growth, migration and capillary tube formation[J]. Life Sci, 2004,76(7): 813-826. [16] Tsai YJ, Chen IL, Horng LY, et al. Induction of differentiation in rat C6 glioma cells with Saikosaponins[J]. Phytother Res, 2002,16(2): 117-121. [17] Hsu YL, Kuo PL, Chang LC, et al. Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines[J]. Cancer Lett,2004,213(2): 213-221. [18] Wen-Sheng W. ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a[J]. Oncogene, 2003,22(7): 955-963. [19] 布世忠, 许金廉. 柴胡皂苷d上调HL-60细胞糖皮质激素受体mRNA并诱导细胞凋亡[J]. 中华血液学杂志, 1999, 20(7): 354-356. [20] Cheng CC, Yang SM, Huang CY, et al. Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells[J]. Cancer Chemother Pharmacol, 2005,55(6): 531-540. [21] Haridas V, Nishimura G, Xu ZX, et al. Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities[J]. PLoS One,2009, 4(5): e5578. [22] 刘萍,边强. 金合欢属树提取物有抗癌作用[J]. 国外医药-合成药、生化药、制剂分册, 2002,23(3): 186. [23] Mujoo K, Haridas V, Hoffmann JJ, et al. Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis[J]. Cancer Res,2001,61(14): 5486-5490. [24] Auyeung KK, Cho CH, Ko JK. A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene[J]. Int J Cancer, 2009,125(5): 1082-1091. [25] Kang XM, Zhang QY, Tong DD, et al. Experimental study on anti-angiogenesis in mice with Lewis lung carcinoma by low-dose of cyclophosphamide combined with ginsenoside Rg3[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi,2005,25(8): 730-733. [26] Leung KW, Cheung LW, Pon YL, et al. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor[J]. Br J Pharmacol, 2007,152(2): 207-215. [27] Tian F, Zhang X, Tong Y, et al. PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo[J]. Cancer Biol Ther, 2005,4(8): 874-882. [28] Hua H, Feng L, Zhang XP, et al. Anti-angiogenic activity of julibroside J8, a natural product isolated from Albizia julibrissin[J]. Phytomedicine, 2009,16(8): 703-711. [29] Wakabayashi C, Hasegawa H, Murata J, et al. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration[J]. Oncol Res, 1997,9(8): 411-417. [30] Xu TM, Cui MH, Xin Y, et al. Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis[J]. Chin Med J (Engl), 2008,121(15): 1394-1397. [31] Lee KJ, Hwang SJ, Choi JH, et al. Saponins derived from the roots of Platycodon grandiflorum inhibit HT-1080 cell invasion and MMPs activities: regulation of NF-kappaB activation via ROS signal pathway[J]. Cancer Lett, 2008,268(2): 233-243. [32] 王长秀,马润娣,于立坚. 土贝母皂苷对人高转移巨细胞肺癌PGCL3细胞侵袭行为的影响[J]. 中国临床药理学与治疗学, 2006,11(1): 39-44. [33] Chang WW, Yu CY,Lin TW,et al. Soyasaponin I decreases the expression of alpha2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cells[J]. Biochem Biophys Res Commun, 2006,341(2): 614-619. [34] Berhow MA,Wagner ED, Vaughn SF, et al. Characterization and antimutagenic activity of soybean saponins[J]. Mutat Res, 2000,448(1): 11-22. [35] Haridas V, Hanausek M, Nishimura G, et al. Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery[J]. J Clin Invest, 2004,113(1): 65-73. [36] Ellington AA, Berhow MA, Singletary KW. Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins[J]. Carcinogenesis, 2005,26(1): 159-167. [37] Ellington AA, Berhow MA, Singletary KW. Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells[J]. Carcinogenesis, 2006,27(2): 298-306. [38] Zong Z, Fujikawa-Yamamoto K, Ota T, et al. Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells[J]. Cell Struct Funct, 1998,23(5): 265-272. [39] Xia LJ, Han R. Differentiation of B16 melanoma cells induced by ginsenoside RH2[J]. Yao Xue Xue Bao, 1996,31(10): 742-745. [40] Chen MH, Chen SH, Wang QF, et al. The molecular mechanism of gypenosides-induced G1 growth arrest of rat hepatic stellate cells[J]. J Ethnopharmacol, 2008,117(2): 309-317. [41] 胡章,马润娣,于立坚. 土贝母皂苷对HL-60细胞周期作用的研究[J]. 肿瘤治疗杂志, 2005, 12(3): 177-179. [42] 于立坚,马润娣,于延曦. 土贝母苷甲和苷乙的抗肿瘤作用[J]. 中国新药杂志, 2002,11(9): 692. [43] Oh SH, Lee BH. A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage[J]. Toxicol Appl Pharmacol, 2004,194(3): 221-229. [44] 布世忠,许金廉. 柴胡皂苷d上调HL-60细胞糖皮质激素受体mRNA并诱导细胞凋亡[J]. 中华血液学杂志, 1999,20(7): 354-356. [45] Wang J, Zhao XZ, Qi Q, et al. Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo[J]. Food Chem Toxicol, 2009,47(7): 1716-1721. [46] Auyeung KK, Law PC, Ko JK, et al. Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line[J]. Int J Mol Med,23(2): 189-196. [47] 马朋,曹同涛,刘栋,等. 薯蓣皂苷类化合物体外抗肿瘤作用的研究[J]. 滨州医学院学报, 2008,31(5): 326-328. [48] Hu K, Yao X. The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro[J]. Phytother Res, 2003,17(6): 620-626. [49] Li W, Liu Y, Zhang JW, et al. Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in vitro: mechanism and possible structure-activity relationship investigation[J]. Arch Pharm Res, 2009,32(1):49-57. [50] Gurfinkel DM, Rao AV. Soyasaponins: the relationship between chemical structure and colon anticarcinogenic activity[J]. Nutr Cancer, 2003,47(1): 24-33. |
[1] | CHEN Yugang, TU Yanqiong, WANG Congqing, CHEN Juan, ZHANG Bohong. Network pharmacology and molecular docking to discuss the mechanism of Jinhutongdan prescription in the treatment of cholelithiasis and experimental verification [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(10): 1090-1098. |
[2] | TIAN Dahao, LU Linming, ZHI Hui, ZHOU Jue, WANG Xiaoqing, JIANG Yuhua. AHVAC-I inhibits the proliferation in human primary gastric cancer cells [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(5): 505-511. |
[3] | QI Qin, HE Xiang, WANG Gang, NA Sha, LV Lei, CHEN Guangliang. Anti-inflammatory and analgesic effects of total saponin of Dioscorea [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(3): 257-264. |
[4] | DUAN Jinning, XIANG Changqing, QIAN Aihong, LI Jin, CHEN Xiuquan, HAN Yongfeng, HUANG Na, FAN Lili. Saponins from Rhizoma Panacis Majoris protect against cerebral ischemia and reperfusion injury through modulation of PI3K/Akt signaling pathway in mice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(7): 750-758. |
[5] | YU Jing, ZHAO Hailan, CHENG Kaiyao, SHEN Pingyu, HUANG Jinlin. Astragalus saponins inhibit high glucose-induced autophagy in human retinal pigment epithelial cells by regulating protein kinase R-like endoplasmic reticulum kinase pathway [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(4): 361-368. |
[6] | NA Sha, DUAN Chenfangyuan, WANG Lu, LV Lei, CHEN Guangliang. Effects and mechanism of total saponins of Achyranthes on acute gouty arthritis in rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(9): 966-971. |
[7] | LI Hui, CHEN Jun, XU Caihong, PANG Linrong, CHENG Xiaochun. Antitumor effect of salvianolic acid A and on its reversal of multidrug resisitance in A549/MTX tumor [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(11): 1244-1247. |
[8] | DENG Junli, ZHANG Rui, TANG Jie, WANG Guo, ZHU Yuanshan. Research progress on the anti-tumor effects of statins [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(1): 92-99. |
[9] | CHEN Yan, YE Bin, MOU Wen-yuan, YU Cheng-bo, LIN Bu, YIN Xiang-peng, XU Hong-miao. Effect of anti-tumor necrosis factor antibody on TRAIL and TNF-α expression induced by lipopolysaccharide in human periodontal ligament fibroblasts [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(5): 493-498. |
[10] | YANG De-xuan, LI Lin-na, WANG Shan-shan, YUAN Shou-jun. Evaluation of anti-tumor effect of epothilone B on human lung cancer A549 cell in vitro and in vivo [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1201-1205. |
[11] | LIU Ai-hua1, SHI Meng-qiong1, YAN Wen-yan1, YANG Wei-hong1, GONG Xue-qian1, XIONG Yan-qiang1, ZHOU Ji-gang2, LUO Tao2, ZHANG Ji-hong2. Cardioprotective effect and its mechanism of total saponin from Panacis majoris rhizoma on myocardium ischemia/reperfusion injury in rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(11): 1224-1232. |
[12] | JIANG Hui, GAO Jia-rong, CHEN Jin-feng, LIU Yong. Hepatoprotective effect of Panax notoginseng saponins in hepatic fibrosis rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(10): 1116-1120. |
[13] | CHEN Liang-jin, SHI Meng-qiong, HE Hai-bo, XIONG Xing-jun, LU Xun-cong. Protective effects of total saponin from Panacis majoris rhizoma against H2O2-induced apoptosis in neonatal rat cardiomyocytes [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(8): 860-867. |
[14] | CHEN Shu-qing, ZHONG Zheng-ling, LI Hai-tao, LI Juan, CHU Ji-ru. Research progress on chemical constituents and pharmacological effects of poplar bud extracts [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(11): 1302-1306. |
[15] | LI Juan, WANG Hai-tao. Intervention activity of lychee seed saponin against rats with senile dementia and its mechinisms [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(10): 1098-1102. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||