Magnesium sulphate alleviated remifentanil induced postoperative hyperalgesia

Abstract

Abstract: AIM: To evaluate the effect of magnesium sulphate (a NMDA-recepter antagonist) on remifentanil-induced postoperative hyperalgesia. METHODS: Seventy-five patients undergoing scoliosis surgery (ASA I-II, aged 10-25 years) were randomly assigned to three groups (n = 25): Group S(intraoperative remifentanil at 0.05μg· kg^-1·min^-1) ;Group R (intraoperative remifentanil at 0.4μg·kg^-1·min^-1) ;Group M (intraoperative remifentanil at 0.4μg·kg^-1 ·min^-1, accompany with induction dose of 40 mg/kg magnesium sulphate, followed by an intraoperative infusion of 20 mg·kg ^-1·h^-1 till the end of surgery). Patient controlled intravenous analgesia (PCA) was performed with fentanyl after operation. Cumulative injected volume of the PCA and pain scores were recorded during 48 postoperative hours.RESULTS: During 36h and 48h postoperative fentanyl consumption was less in Group Sthan that of Group R (P <0.05).During 24 h, 36 h and 48 h postoperative fentanyl consumption was less in Group M than that of Group R (P <0.01).There were no significant differences in pain scores in the three groups.CONCLUSION: Intraoperative infusion of remifentanil at 0.4μg·kg^-1·min^-1 triggers postoperative secondary hyperalgesia.Perioperative magnesium sulphate supplementation could alleviate the hyperalgesia induced by remifentanil.

Key words: Hyperalgesia, Remifentanil, Magnesium sulphate, N-methy l-D-aspartate

CLC Number:

R614.2

GU Wei, GU Xiao-ping, ZHANG Xiao-kun, ZHANG Jing, MA Zheng-liang. Magnesium sulphate alleviated remifentanil induced postoperative hyperalgesia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(1): 93-97.

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