Phosphodiesterase 3: new targets for drug development

Abstract

Abstract: Phosphodiesterase (PDE) is hydrolase of 3', 5'-cyclic adenosine monophosphate (cAMP) and 3', 5'-cyclic guanosine monophosphate (cGMP). PDE3 are composed of two genes and distributed widely in vivo.Its inhibitors have been applied in antiplatelet aggregation and vasodilation.It has been reported that PDE3 inhibitors have neuroprotective effects on cerebral ischemia, which may provide new methods to prevention and therapy of cerebral ischemia.

Key words: phosphodiesterase (PDE), neuroprotection, cerebral ischemia

CLC Number:

YE Yi-lu, ZHANG Qi, YU Yue-ping. Phosphodiesterase 3: new targets for drug development[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(6): 711-715.

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