Research progress on traditional Chinese medicine affecting the metabolism of cytochrome P450

Abstract

Abstract: Cytochrome P450 is one of the microsomal mixed function oxidase, and plays an important role in the metabolism of exogenous and endogenous material.Lots of domestic and overseas relative literatures were red, the article summarized the research progress of traditional Chinese medicine affecting the metabolism of CYP in recent years.Eight main drugmetabolizing enzymes were respectively introduced, including CYP1A1, CYP1A2, CYP2A6, CYP2C, CYP2D6, CYP2E1, CYP3A4 and CYP3A4.It is important to research CYP450 for drug screening, individual administration.

Key words: traditional Chinese medicine, CYP, research in progress

CLC Number:

R285.6

XIE Rui-fang, ZHOU Xin. Research progress on traditional Chinese medicine affecting the metabolism of cytochrome P450[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(6): 697-700.

References

[1] 朱立勤, 娄建石.细胞色素P450 与药物代谢的研究现状[J].中国临床药理学与治疗学, 2004, 9(10):1081-1086.
[2] Yang XF, Wang NP, Lu WH, et al.Effects of Ginkgo biloba extract and glutathinone on cytochrome P450 isozymes and glutathione transferanse in rats[J].Acta Pharmacol Sin, 2003, 24(10):1033-1038.
[3] 马世玉, 李莉, 吴基良, 等.丹参酮对大鼠细胞色素P450 酶系和谷胱甘肽转移酶的作用[J].咸宁学院学报, 2005, 19(1):14-16.
[4] 王宇光.人参、藜芦合用对大鼠肝P450 酶活性及mRNA 表达的调控作用[J].中国中药杂志, 2004, 29(4):366-370.
[5] 赵立子, 马锦芳, 邓颖, 等.银杏叶提取物对细胞色素P450 酶CYP1A2 实验研究[J].中国临床药理学杂志, 2005, 2(21):122-125.
[6] 刘树民, 张琳, 李颖, 等.黄药子与当归配伍对大鼠肝脏CYP1A2、CYP2E1 基因mRNA 表达的影响[J].中药药理与临床, 2006, 22(3):97-98.
[7] Ma XC, Xin J, Zhang T, et al.Effects of huperzine A on liver cytochrome P450 in rats[J].Acta Pharmacol Sin, 2003, 24(80):831-835.
[8] 杜瑜, 朱荣华, 苏芬丽, 等.齐墩果酸对健康人体CYP1A2, CYP2E1 及CYP3A4 抑制作用的研究[J].中国药学杂志, 2008, 43(4):300-303.
[9] 高月.PL-6 基于药物代谢酶的中药毒性与毒理研究[J].毒理学杂志增刊, 2005, 3(19):175.
[10] Kleiner HE, Vulimiri SV, Reed MJ, et al.Role of cytochrome P450 1A1 and 1B1 in the metabolic activation of 7, 12-dimethylbenz[a] anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation [J].Chem Res Toxicol, 2002, 15(2):226-235.
[11] Takahashi E, Fujita K, Kamataki T, et al.Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin[J].Mutat Res, 2002, 508(1/2):147-156.
[12] Mohutsky MA, Anderson GD, Miller JW, et al.Ginkgo biloba:evaluation of CYP2C9 drug interactions in vitro and in vivo[J].Am J Ther, 2006, 13(1):24-31.
[13] He N, Edeki T.The inhibitory effects of herbal components on CYP2C9 and CYP3A4 catalytic activities in human liver microsomes[J].Am J Ther, 2004, 11(3):206-212.
[14] Komoroski BJ, Zhang S, Cai H, et al.Induction and inhibition of cytochromes P450 by the St.John's wort constituent hyperforin in human hepatocyte cultures[J].Drug Metab Dispos, 2004, 32(5):512-518.
[15] 曹亚杰, 曹伟, 余奇, 等.吴茱萸次碱在人肝微粒体中对细胞色素P450 酶的抑制作用[J].中南药学,2005, 3(4):243-245.
[16] 王启斌, 狄伟, 程晓莉, 等.葛根素对细胞色素P450 酶活性的影响[J].医药导报, 2008, 27(5):500-503.
[17] 于卫江, 黄丽军, 朱大岭.应用大鼠肝微粒体筛选对细胞色素P4502D6 有抑制作用的中药[J].中草药, 2007, 38(3):397-401.
[18] 代方国, 罗仁, 王宇光, 等.甘遂配伍甘草对大鼠肝脏CYP2E1 表达及活性的影响[J].第三军医大学学报, 2005, 27(8):742-744.
[19] 刘树军, 黄静娟, 车念聪.活血化痰基础方对大鼠非酒精性脂肪肝模型CYP2E1 活性的影响[J].中西医结合肝病杂志, 2008, 18(2):109-111.
[20] 刘艳, 李天骄, 赵锦燕, 等.粗叶悬钩子粗多糖对模型大鼠急性肝损伤药物代谢酶的影响[J].福建中医学院学报, 2008, 18(2):13-15.
[21] Gurley BJ, Gardner SF, HubbardMA, et al.Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly:St John's wort, garlic oil, Panax ginseng and Ginkgo biloba[J].Drugs Aging, 2005, 22(6):525-539.
[22] Ingeman SM.Pharmacogenetics of cytochrome P450 and its applications in drug therapy:the past, present and future[J].Trends Pharmacol Sci, 2004, 25(4):193-200.
[23] 吴宁, 雷霆雯, 李红梅, 等.漏芦对大鼠肝细胞CYP3A1 酶活性及其mRNA 表达的影响[J].中药材,2007, 30(11):1403-1406.
[24] Patel J, Buddha B, Dey S, et al.In vitro Interaction of the HIV Protease Inhibitor Ritonavir with Herbal Constituents: Changes in P-gp and CYP3A4 Activity[J].Am J Ther, 2004, 11(4):262-277.
[25] Godtel-Armbrust U, Metzger A, Kroll U, et al.Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St John's wort[J].Naunyn Schmiedebergs Arch Pharmacol, 2007, 375(6):377-382.