Abstract: AIM: To investigate the effect of ginkgo leaf extract on oxidative stress and haemodynamics of diabetic nephropathy(DN).METHODS: The patients of DN were divided into ginkgo leaf extract treatment group and control group.The changes of serum superoxide dismutase (SOD), glutathione peroxidase(GSHPx), malondialdehyde (MDA)and hemorheology indexes were observed.RESULTS: Before treatment, serum SOD, GSH-Px, MDA and hemorheology indexes had no significant difference between ginkgo leaf extract treatment group and control group.After treatment, the serum levels of T-SOD and GSH-Px were increased; the level of MDA, hemorheology indexes, erythrocyte aggregation index and platelet aggregation rate were decreased significantly in ginkgo leaf extract treatment group compared with those in control group (P<0.01).CONCLUSION: The antioxidant ability of cells were deceased in DN.Ginkgo leaf extract could protect the renal function by increasing the activities of SOD and GSH-Px, improving the hemorheology, decreasing the albuminuria.

Key words: ginkgo leaf extract, diabetic nephropathy, oxidative stress, hemorrheology