Research status quo and development of herbs and chemical medicines interactions

Abstract

Abstract: Herbs are naturally occurring drugs which were extracted from plants, generally, they come from traditional Chinese medicine.Recently, there are a drastic growth in the combination use of herbs and chemical medicines, which leads to a large number of drug interactions and adverse effects.The CYP450 enzymes and some ABC transporters in human body play an important role in these interactions.Further and deeper researches in this field would be necessary and important to decrease such interactions and guide the safe and rational use in clinic.The paper introduces the drug interactions and latest study progress of common herbs and chemical medicines, it will offer a reference for the research.

Key words: herb, chemical medicine, p-glycoprotein, CYP450, drug interaction

CLC Number:

R969.2

LIU Zhi-feng, ZHOU Hong-hao. Research status quo and development of herbs and chemical medicines interactions[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(2): 214-219.

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