Abstract: AIM: To investigate the effects of Chishaoganaochongji D-galactosamine-induced liver injury in mice.METHODS: The chemical-associated liver injury in mouse was induced made by administration of DGalN.The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level, and malondiadehyde(MDA) and nitric oxide (NO) level in liver homogenate were assayed by chemochromometry.RESULTS: Chishaogancaochongji (200, 400, 800 mg·kg^-1)was able to decrease levels of serum transaminases (ALT,AST) , liver index and thymus index significantly.Furthermore,Chishaogancaochongji also decreased MDA content and NO level in liver homogenate.CONCLUSION: Chishaogancaochongji has protective effect on chemicalassociatedliver injury in mice.

Key words: mice, Chishaogancaochongji, D-galactosamine, chemochromometry, chemical liver injury