Abstract: AIM: To investigate the pharmacokinetics and relative bioavailability of shuanghuanglian injection in rabbits by rectal medication in comparison with oral medication.METHODS: Chlorogenic aci from flos loniceraed,a main component in shuanghuanglian injection,was used as a detection marker in blood drug.According to the velocity of drug entering into systemic circulation from medication site(that is,absorption rate K_a)and the relative quantity of drug entering into systemic circulation from medication site(that is,absorption degree),AUC was usually used as a marker to observe absorption dynamic changes of rectal medication.RESULTS: There was significant difference of AUC between clusis groupand oral group(p<0.05).Bioavailability of enema was 100%,and oral dose 80.87%;The values of T_p of enema and oral dose were 0.75 h and 2.48 h,respectively(p<0.05),showing that clusis was superior to oral medication;C_max was affected by absorption quantity and time.There was significant difference of C_max between enema and oral dose(p<0.05),showing that the blood drug concentration of enema was obviously higher than that of oral dose.CONCLUSION: For the chlorogenic acid from shuanghuanglian injection,the absorption in rectal medication is faster than that in oral medication,and the blood concentration,total absorption quantity and bioavailability of rectal medication are higher than ones of oral medication.

Key words: chronic pelvic inflammatory disease, traditional Chinese medicine, pharmacokinetics, rectal medication