Abstract: Aim The Effect and mechanismof human placental extract(HPE) on the lipoprotein-c holesterol metabolism, peroxidation and the function of platelet agg reg ation in hyperlipaemiarats wereabserved.Methods Wistarrat with hyperlipaemia models weregiven each HPE 0.4 ml (100 g)^-1·d^-1 throug h lavage for 12 days.The serum levels of TG, TC, LDL-C, HDL-Cand HDL 2-C in its subgroup weremeasured.The activies of LPO and SOD in both blood and liver tissue weredeter mined.The Effect of HPE on lipidosis of liver wereabserved by fat dy eing.The levels of 6-keto-PG F1α, TXB 2 in plasma and maximum platelet agg regation rate were measured by ELASA.Result The levels of HDL-Cand HDL2-C wereincreased (P<0.01)whilethe levels of TG, TCand LDL-C weredecreased (P<0.01).The levels of LPO in serum and liver tissue decreased obviously and SOD activity increased (P<0.01).The lipidosis in liver was inhibited and adipose hollow spacereduced obviously.The levels of PG I2 in plasma increased (P<0.01), the level of T XB 2 was no t changed and platelet agg reg ation rate was decreased obviously.Conclusion HPE may improve the lipoprotein-cholesterol metabolism, enhance the antioxidation andinhibite platelet aggregation and the formation of lipidosis of liver in hyperlipemiarats.HPE is good for inhibition of the formation and development of atheoscleorsis.

Key words: human placental extract, lipoprotein-cholesterol metabolism, liperoxide, superoxide dismutas, 6-ke to-PGF1α, platelet agg reg ates