Abstract: Aim The effect triptolide(Tri)on local stimulation was observed.Methods Trisolution in different concentrations was appliedin rabbits, rats and mice and therespenses wereobserved.Results 1.11, 2.22 and 4.44 mmol·L^-1 of Tri induced obviousery thema and edema on both intact skin andinjured skin of rabbits.The pathological histology revealed the evidentinf lammation in scarf skin and corium 2.22 mmol·L^-1 and 4.44 mmol·L^-1 of triptolide significantly induced swelling of auricle in mice.0.55 mmol·L^-1 and 1.11 mmol·L^-1 of Trisignificantly induced swelling of planta in rats.Theresponse ofinflammation reached topeak at the third day after hypodermic injection and lasted a week.Tri also significant ly induced pain reaction and enhanced the permeability of capillary after local injection in mice.Conclusion Tri has a local stimulation effect andinduces inflammation which can no t be antagoni zed by its anti-inflammation Effect.

Key words: Tri, stimulation, inflammation, pain