Abstract: AIM: To explore the changes in immune function children patients with repeated respiratory infection (RRI) and the influence of nucleotide and casein injection on it.METHODS: 45 patients with RRI were arranged in therapy group and were injected with nucleotide and casein injection.32 patients with acute respiratory infection were arranged in control group who were not injected with nucleotide and casein injection.The effect of treatment, change of IgA, IgG, IgM, T-lymphocyle subgroups and reaction intensity of PHA were observed.RESULTS: There were very significant decline of IgA and IgG level (P <0.01, P <0.05) in RRI children than those in control group.The IgA level in RRI increased obviously after treatment with nucleotide and casein injection (P <0.05).There were very significant decline of CD₄, CD₄/CD₈ and NK cells levels (P <0.05, P < 0.01) in RRI children than those in control group.The CD₄, NK cells levels in RRI obviously increased after treatment with nucleotide and casein injection (P < 0.05).The roseola diameter of PHA in RRI children declined significantly (P <0.05).There were obviously increase in roseola diameter of PHA after treatment with nucleotide and casein injection (P <0.05).CONCLUSION: Nucleotide and casein injection boosts and improves cell immunity and fluid immunity.

Key words: children, repeated respiratory infection, immune function, nucleotide and casein injection