Abstract: AIM: To demonstrate the protective effects of ST-1 against focal cerebral ischemia-reperfusion injury in rats.METHODS: The model of focal ischemiareperfusion was induced by middle cerebral artery occlusion 2 h followed by reperfusion 22 h in rats.Neurological deficit scores were evaluated.Infarct size, malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were measured, pathological changes of neurons in hippocampal CA1 region were observed.RESULTS: Compared with vehicle group ST-1 at dose of 10 and 20 mg·kg ^-1 could reduce the infarct size, MDA content, enhance SOD activity and relieve neurons injury in hippocampal CA1 region in dose-dependent way;ST-1 at dose of 20 mg·kg ^-1 could also improve neurological function. CONCLUSION: ST-1 can protect brain tissue from focal ischemia-reperfusion injury.

Key words: arteria cerebri media, cerebral ischemia reperfusion, oxygen radicals, nimodipine, rat