Effects of propofol and isoflurane on general brain ischemia-reperfusion injury in rats

Abstract

Abstract: AIM: To explore the effects of propofol and isoflurane on total cerebral ischemia-reperfusion inju-ry of rats.METHODS: Male SD rats were randomly di-vided into two grougs (n =14), which were respectively anesthetized with propofol and isoflurane under mechani-cal ventilation.Global cerebral ischemia was induced by occlusions of bilateral common carotid and vertebral arter-ies (four vessels).Each group was divided into two sub-groups according to reperfusion time:30 min for detecting MDA and SOD in brain tissues and 3 d for detecting sur-vived CA1 Cells of hippocampus.RESULTS: The cont-ents of MDA was more after 30 min reperfusion in isoflu-rane group than that in propofol group (P<0.01), whereas the activities of SOD was higher in propofol group than that in isoflurane group(P<0.01).There were more survived neurons in CA1 after 3 day reperfusion in propofol group than in isoflurane group(P<0.05). CONCLUSION: Propofol has stronger protection effect in general brain ischemia-reperfusion injury, the mecha-nism is associated with the activity of oxide free radical.

Key words: propofol, isoflurane, cerebral ischemia-reperfusion, hippocampus

CLC Number:

R965.1

WANG Shi-lei, WANG Shi-duan, LI Yu, LIU Chuang-sheng, PAN Wei-ming, ZHANG Lin. Effects of propofol and isoflurane on general brain ischemia-reperfusion injury in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(5): 562-564.

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