Naringin is a flavonoid compound with a wide range of biological and pharmacological activities, which can be used in treating tumor, diabetes, neurodegenerative diseases, cardiovascular diseases, metabolic syndrome, etc. Among them, the application of naringin in cardiovascular diseases has attracted the attention of many researchers. This article mainly reviews the role of naringin in cardiovascular disease (regulating blood lipids, anti atherosclerosis, lowering blood pressure, inhibiting myocardial hypertrophy, anti myocardial infarction, protecting myocardial ischemia/reperfusion injury, reducing myocardial ischemia/reperfusion injury and improving pulmonary arterial hypertension), the protective effect on cardiotoxicity, and the signal pathways in cardiovascular disease (PI3K-Akt-mTOR, p-eNOS/p-Akt/p-ERK, miR-126/GSK-3 β/β-Catenin), clinical trials, etc. This paper is expected to review the current research status of naringin in cells and animal models so as to reveal its clinical application prospects and provide reference for further research in related fields.