The neuroprojective effects of lamotrigine on rat global cerebral ischemic reperfusion damage

Abstract

Abstract: AIM: To investigate the neuroprojective effects of lamotrigine on rat global cerebral ischemic reperfusion damage. METHODS: Pulsinelli's method was employed to establish cerebral ischemia reperfusion animal model. The dynamic varieties of Glu, patho-change of brain tissue and neurocyte apoptosis were observed after giving lamotrigine. RESULTS: (1) Basic levels of Glu in acute ischemia and reperfusion group and LTG group were same as sham group's. They improved swiftly after lack blood, and reached peak after the brain reperfusion 30 min, then gradually fell. The levels of acute ischemia and reperfusion group were notability higher than sham group's in 30-330 min (P<0.05). The levels of LTG group were notability higher than sham group's, and lower than acute ischemia and reperfusion group's in 30-330 min (P<0.05). (2) By the method of TdT-mediated Dutp-biotin nick end-labeling, positive apoptosis cell in LTG group were decreased remarkably than in acute ischemia and reperfusion group (P<0.05). CONCLUSION: After cerebral ischemia and reperfusion, lamotrigine can reduce the amount of excitatory amino acids, and enhance nerve cell's living rate, and provide obvious protective effects .

Key words: Lamotrigine, Glutamate, Microdialysis, Apoptosis

CLC Number:

R965.2

MAO Jie, JIANG Xiao-chun, XU Shan-shui, WANG Xuan-zhi. The neuroprojective effects of lamotrigine on rat global cerebral ischemic reperfusion damage[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(10): 1105-1109.

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