Effects of Naringin on expression of p38MAPK and ERK1/2 signaling proteins of Human ovarian cancer cell line SKOV3

Abstract

Abstract: AIM: To investigate effects of Naringin on expression of P38MAPK and ERK1/2 signaling proteins of Human ovarian cancer cell line SKOV3.METHODS: SKOV3 cell were cultured in vitro and divided into five groups randomly, namely control group, naringin group (10 μmol/L), naringin group (20 μmol/L), naringin group (40 μmol/L) and celecoxib group (80 μmol/L). The expression of P38MAPK and ERK1/2 signaling proteins were determined by Western Blot after forty-eight hours.RESULTS: Compared with control group, only naringin group (40 μmol/L) and celecoxib group can significantly cut P38MAPK and ERK1/2 signaling proteins, the difference was statistically significant (P<0.05).CONCLUSION: Naringin can inhibit P38MAPK and ERK1/2 signaling proteins of SKOV3 cell, thus may block the occur and development of ovarian cancer.

Key words: Naringin, P38MAPK, ERK1/2, Ovarian cancer, Cell SKOV3

CLC Number:

R965.2

HU Xin, SONG Shu-hui, XIONG Yu-qing, CAI Li-ping. Effects of Naringin on expression of p38MAPK and ERK1/2 signaling proteins of Human ovarian cancer cell line SKOV3[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(5): 519-523.

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