Effects of Liuweidihuang Formula (LWDHF) on ET,TXA2,PGI2 and protecting the endotheliocytes in the blood plasma of rats with hyperlipidemia

Abstract

Abstract: AIM: To observe the effects of Liuweidihuang Formula (LWDHF) on ET,TXA₂,PGI₂ and protecting the endotheliocytes in the blood plasma of rats with hyperlipidemia.METHODS: The hyperlipidemia rat model was established by feeding high cholesterol diet. Circulating endothelial cells (CEC) in peripheral blood and the pathological change of aortas were detected. Meanwhile the levels of plasma Endothelin (ET) , prostaglandin I₂ (PGI₂),thromboxane A₂ (TXA₂) were measured.RESULTS: LWDHF could decrease CEC in peripheral blood and the injury of aortic endothelial cells in hyperlipidemia rats,and the levels of plasma ET, TXA₂ were decreased, the level of PGI₂ was increased.CONCLUSION: LWDHF might protect vascular endothelial cells of hyperlipidemia rat. The mechanism may relate to improve the secretion function of endothelial cell.

Key words: Liuweidihuang Formula, endothelin (ET), thromboxane(TXA₂), prostaglandin (PGI₂), vascular endothelial cell

CLC Number:

R965.2

YU Li-zhen, BIAN Hui-ming , YU Jing-hua. Effects of Liuweidihuang Formula (LWDHF) on ET,TXA₂,PGI₂ and protecting the endotheliocytes in the blood plasma of rats with hyperlipidemia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(5): 503-506.

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Effects of Liuweidihuang Formula (LWDHF) on ET,TXA₂,PGI₂ and protecting the endotheliocytes in the blood plasma of rats with hyperlipidemia

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