A new regulatory target of the metabolic syndrome :the farnesoid X receptor

Abstract

Abstract: The farnesoid X receptor(FXR) is a nuclear receptor of bile acids, which plays an important role in bile acid regulation, lipid and glucose homeostasis. It associates with metabolic syndrome closely. Thus, FXR is probably a new regulatory target in the treatment of metabolic syndrome.This paper discusses the research progress about the FXR and bile acid regulation, lipid and glucose homeostasis.

Key words: FXR, bile acid, lipid metabolism, glucose metabolism

CLC Number:

R589

ZHU Hong, XU Zhu-mei, XIAO Jian. A new regulatory target of the metabolic syndrome :the farnesoid X receptor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1312-1316.

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